Linked Life Data

10769777

Source:http://linkedlifedata.com/resource/pubmed/id/10769777

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2000-6-29
pubmed:abstractText
The effect of particle morphology of the components on the physical stability of ordered mixtures was determined for a model system comprised of a mixture of micronized aspirin and a monodisperse carrier. Spray-dried lactose, crystallized lactose, microcrystalline cellulose, and dextrate were used as carriers. The surface texture of the carriers was quantified in terms of the ratio of the perimeter of the particles to that of an idealized shape at a constant magnification. Mixtures containing highly textured carriers segregated to a lesser extent than those containing smoother textured carriers. This was postulated to be due to the presence of a higher concentration of surface asperities on the coarse carriers that can constitute potentially strong adhesion sites for the fine component because of their higher energy relative to adjacent areas on the surface. The effect of the addition of a ternary component, magnesium stearate, on the stability of the above mixtures was studied. The observed differences in the segregation response were attributed to electrostatic charge effects.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0363-9045
pubmed:author
pubmed:issnType
Print
pubmed:volume
26
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
365-73
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2000
pubmed:articleTitle
The effect of particle morphology on the physical stability of pharmaceutical powder mixtures: the effect of surface roughness of the carrier on the stability of ordered mixtures.
pubmed:affiliation
Department of Industrial and Physical Pharmacy, Purdue University, West Lafayette, IN 47907, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't