Source:http://linkedlifedata.com/resource/pubmed/id/10769064
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
Pt 5
|
| pubmed:dateCreated |
2000-6-9
|
| pubmed:abstractText |
Interleukin-18 (IL-18) is a proinflammatory cytokine that plays a key role in the activation of natural killer and T helper 1 cell responses principally by inducing interferon-gamma (IFN-gamma). Human and mouse secreted IL-18-binding proteins (IL-18BPs) have recently been described which block IL-18 activity but have no sequence similarity to membrane IL-18 receptors. Several poxvirus genes encode proteins with sequence similarity to IL-18BPs. Here we show that vaccinia, ectromelia and cowpox viruses secrete from infected cells a soluble IL-18BP (vIL-18BP) that may modulate the host antiviral response. The ectromelia virus protein was found to block NF-kappaB activation and induction of IFN-gamma in response to IL-18. The highly attenuated vaccinia virus modified virus Ankara encodes IL-18-binding activity, and thus deletion of the vIL-18BP may improve further the safety and immunogenicity of this promising human vaccine candidate. We confirm that molluscum contagiosum virus, a molluscipoxvirus that produces small skin tumours in immunocompetent individuals and opportunistic infections in immunodeficient AIDS patients, also encodes a related, larger vIL-18BP (gene MC54L). This protein may contribute to the lack of inflammatory response characteristic of molluscum contagiosum virus lesions. The expression of vIL-18BPs by distinct poxvirus genera that cause local or general viral dissemination, or persistent or acute infections in the host, emphasizes the importance of IL-18 in response to viral infections.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Culture Media,
http://linkedlifedata.com/resource/pubmed/chemical/Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Intercellular Signaling Peptides...,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/interleukin-18 binding protein
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| pubmed:status |
MEDLINE
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| pubmed:month |
May
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| pubmed:issn |
0022-1317
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
81
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1223-30
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:10769064-Amino Acid Sequence,
pubmed-meshheading:10769064-Animals,
pubmed-meshheading:10769064-Baculoviridae,
pubmed-meshheading:10769064-Cell Line,
pubmed-meshheading:10769064-Cowpox virus,
pubmed-meshheading:10769064-Culture Media,
pubmed-meshheading:10769064-Ectromelia virus,
pubmed-meshheading:10769064-Glycoproteins,
pubmed-meshheading:10769064-Humans,
pubmed-meshheading:10769064-Intercellular Signaling Peptides and Proteins,
pubmed-meshheading:10769064-Mice,
pubmed-meshheading:10769064-Mice, Inbred BALB C,
pubmed-meshheading:10769064-Molecular Sequence Data,
pubmed-meshheading:10769064-Molluscum contagiosum virus,
pubmed-meshheading:10769064-Orthopoxvirus,
pubmed-meshheading:10769064-Recombinant Proteins,
pubmed-meshheading:10769064-Spleen,
pubmed-meshheading:10769064-Vaccinia virus
|
| pubmed:year |
2000
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| pubmed:articleTitle |
Ectromelia, vaccinia and cowpox viruses encode secreted interleukin-18-binding proteins.
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| pubmed:affiliation |
Division of Virology, Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|