Source:http://linkedlifedata.com/resource/pubmed/id/10768200
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
7
|
| pubmed:dateCreated |
2000-5-22
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| pubmed:abstractText |
Structure-activity relationships of the east and south amino acid modified analogues of rhodopeptins, novel antifungal cyclic tetrapeptides isolated from Rhodococcus species Mer-N1033, have been investigated. It was observed that a basic amino acid moiety (lysine or ornithine) as the east amino acid and a hydrophobic and bulky neutral amino acid (i.e., gamma-methylleucine) as the south amino acid were indispensable structure motifs for antifungal activity of rhodopeptin analogues.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
1523-7060
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
6
|
| pubmed:volume |
2
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
973-6
|
| pubmed:dateRevised |
2000-12-18
|
| pubmed:meshHeading |
pubmed-meshheading:10768200-Amino Acids,
pubmed-meshheading:10768200-Antifungal Agents,
pubmed-meshheading:10768200-Fungi,
pubmed-meshheading:10768200-Microbial Sensitivity Tests,
pubmed-meshheading:10768200-Peptides, Cyclic,
pubmed-meshheading:10768200-Rhodococcus,
pubmed-meshheading:10768200-Structure-Activity Relationship
|
| pubmed:year |
2000
|
| pubmed:articleTitle |
Synthesis and antifungal activity of rhodopeptin analogues. 1. Modification of the east and south amino acid moieties.
|
| pubmed:affiliation |
New Product Research Laboratories I, Daiichi Pharmaceutical Co., Ltd., Tokyo, Japan. kawatlm8@daiichipharm.co.jp
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| pubmed:publicationType |
Journal Article
|