10762050

Source:http://linkedlifedata.com/resource/pubmed/id/10762050

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0021467, umls-concept:C0021469, umls-concept:C0031684, umls-concept:C0033262, umls-concept:C0871161, umls-concept:C1704259, umls-concept:C1705987
pubmed:issue	7
pubmed:dateCreated	2000-8-17
pubmed:abstractText	Phosphopeptide prodrugs bearing two S-acyl-2-thioethyl (SATE) biolabile phosphate protections were developed. They are capable to inhibit the Shc/Grb2 interaction and MAP kinases (ERK1 and ERK2) phosphorylation in cellular assay. The S-acetyl-2-thioethyl (MeSATE) analogue showed an IC50 of 1 microM in the inhibition of the colony formation of tumor cell line NIH3T3/HER2.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/9107377
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Adaptor Proteins, Signal Transducing, http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents, http://linkedlifedata.com/resource/pubmed/chemical/GRB2 Adaptor Protein, http://linkedlifedata.com/resource/pubmed/chemical/Grb2 protein, mouse, http://linkedlifedata.com/resource/pubmed/chemical/Intramolecular Transferases, http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinase 1, http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinase 3, http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinases, http://linkedlifedata.com/resource/pubmed/chemical/Phosphopeptides, http://linkedlifedata.com/resource/pubmed/chemical/Prodrugs, http://linkedlifedata.com/resource/pubmed/chemical/Proteins, http://linkedlifedata.com/resource/pubmed/chemical/ras Proteins, http://linkedlifedata.com/resource/pubmed/chemical/squalene-hopene cyclase
pubmed:status	MEDLINE
pubmed:month	Apr
pubmed:issn	0960-894X
pubmed:author	pubmed-author:GarbayCC, pubmed-author:LinW JWJ, pubmed-author:MathéCC, pubmed-author:PérigaudCC, pubmed-author:VidalMM
pubmed:issnType	Print
pubmed:day	3
pubmed:volume	10
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	669-72
pubmed:dateRevised	2009-11-19
pubmed:meshHeading	pubmed-meshheading:10762050-3T3 Cells, pubmed-meshheading:10762050-Adaptor Proteins, Signal Transducing, pubmed-meshheading:10762050-Animals, pubmed-meshheading:10762050-Antineoplastic Agents, pubmed-meshheading:10762050-GRB2 Adaptor Protein, pubmed-meshheading:10762050-Intramolecular Transferases, pubmed-meshheading:10762050-Mice, pubmed-meshheading:10762050-Mitogen-Activated Protein Kinase 1, pubmed-meshheading:10762050-Mitogen-Activated Protein Kinase 3, pubmed-meshheading:10762050-Mitogen-Activated Protein Kinases, pubmed-meshheading:10762050-Phosphopeptides, pubmed-meshheading:10762050-Phosphorylation, pubmed-meshheading:10762050-Prodrugs, pubmed-meshheading:10762050-Proteins, pubmed-meshheading:10762050-Stem Cells, pubmed-meshheading:10762050-ras Proteins
pubmed:year	2000
pubmed:articleTitle	Inhibition of the ras-dependent mitogenic pathway by phosphopeptide prodrugs with antiproliferative properties.
pubmed:affiliation	Laboratoire de Pharmacochimie Moléculaire et Structurale, U266 INSERM, UMR 8600 CNRS, Faculté de Pharmacie, Paris, France.
pubmed:publicationType	Journal Article, Research Support, Non-U.S. Gov't