|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
1
|
|
pubmed:dateCreated |
2000-4-28
|
|
pubmed:abstractText |
Boronophenylalanine (BPA) and sodium borocaptate (Na(2)B(12)H(11)SH or BSH) have been used clinically for boron neutron capture therapy (BNCT) of high-grade gliomas. These drugs appear to concentrate in tumors by different mechanisms and may target different subpopulations of glioma cells. The purpose of the present study was to determine if the efficacy of BNCT could be further improved in F98-glioma-bearing rats by administering both boron compounds together and by improving their delivery by means of intracarotid (i.c.) injection with or without blood-brain barrier disruption (BBB-D).
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Apr
|
|
pubmed:issn |
0360-3016
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
1
|
|
pubmed:volume |
47
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
209-18
|
|
pubmed:dateRevised |
2006-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:10758326-Animals,
pubmed-meshheading:10758326-Blood-Brain Barrier,
pubmed-meshheading:10758326-Borohydrides,
pubmed-meshheading:10758326-Boron Compounds,
pubmed-meshheading:10758326-Boron Neutron Capture Therapy,
pubmed-meshheading:10758326-Brain,
pubmed-meshheading:10758326-Brain Neoplasms,
pubmed-meshheading:10758326-Drug Screening Assays, Antitumor,
pubmed-meshheading:10758326-Drug Therapy, Combination,
pubmed-meshheading:10758326-Glioma,
pubmed-meshheading:10758326-Injections, Intra-Arterial,
pubmed-meshheading:10758326-Phenylalanine,
pubmed-meshheading:10758326-Radiation-Sensitizing Agents,
pubmed-meshheading:10758326-Radiobiology,
pubmed-meshheading:10758326-Radiotherapy Dosage,
pubmed-meshheading:10758326-Rats,
pubmed-meshheading:10758326-Rats, Inbred F344,
pubmed-meshheading:10758326-Sulfhydryl Compounds,
pubmed-meshheading:10758326-Time Factors
|
|
pubmed:year |
2000
|
|
pubmed:articleTitle |
Boron neutron capture therapy of brain tumors: enhanced survival and cure following blood-brain barrier disruption and intracarotid injection of sodium borocaptate and boronophenylalanine.
|
|
pubmed:affiliation |
Department of Pathology, The Ohio State University, Columbus, OH, USA. barth.1@osu.edu
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.
|
