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rdf:type |
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lifeskim:mentions |
umls-concept:C0152060,
umls-concept:C0205154,
umls-concept:C0205410,
umls-concept:C0282554,
umls-concept:C1306235,
umls-concept:C1332684,
umls-concept:C1444748,
umls-concept:C1512167,
umls-concept:C1518071,
umls-concept:C1523979,
umls-concept:C1705075
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pubmed:issue |
8
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pubmed:dateCreated |
2000-5-9
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pubmed:abstractText |
To test whether accumulation of naive lymphocytes is sufficient to trigger lymphoid development, we generated mice with islet expression of the chemokine TCA4/SLC. This chemokine is specific for naive lymphocytes and mature dendritic cells (DC) which express the CCR7 receptor. Islets initially developed accumulations of T cells with DC, with scattered B cells at the perimeter. These infiltrates consolidated into organized lymphoid tissue, with high endothelial venules and stromal reticulum. Infiltrate lymphocytes showed a naive CD44low CD25- CD69- phenotype, though half were CD62L negative. When backcrossed to RAG-1 knockout, DC were not recruited. Interestingly, islet lymphoid tissue developed in backcrosses to Ikaros knockout mice despite the absence of normal peripheral nodes. Our results indicate that TCA4/SLC can induce the development and organization of lymphoid tissue through diffential recruitment of T and B lymphocytes and secondary effects on stromal cell development.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0022-1767
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
164
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3955-9
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:10754285-Animals,
pubmed-meshheading:10754285-Biological Markers,
pubmed-meshheading:10754285-Cell Movement,
pubmed-meshheading:10754285-Chemokine CCL21,
pubmed-meshheading:10754285-Chemokines, CC,
pubmed-meshheading:10754285-Dendritic Cells,
pubmed-meshheading:10754285-Hematopoiesis,
pubmed-meshheading:10754285-Immunologic Memory,
pubmed-meshheading:10754285-Insulin,
pubmed-meshheading:10754285-Islets of Langerhans,
pubmed-meshheading:10754285-Lymph Nodes,
pubmed-meshheading:10754285-Lymphocyte Activation,
pubmed-meshheading:10754285-Lymphoid Tissue,
pubmed-meshheading:10754285-Mice,
pubmed-meshheading:10754285-Mice, Inbred BALB C,
pubmed-meshheading:10754285-Mice, Inbred C57BL,
pubmed-meshheading:10754285-Mice, Knockout,
pubmed-meshheading:10754285-Mice, Transgenic,
pubmed-meshheading:10754285-Rats
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pubmed:year |
2000
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pubmed:articleTitle |
Cutting edge: ectopic expression of the chemokine TCA4/SLC is sufficient to trigger lymphoid neogenesis.
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pubmed:affiliation |
Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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