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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2000-4-11
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pubmed:abstractText |
A critical early event in the pathogenesis of diabetic retinopathy is leukocyte adhesion to the diabetic retinal vasculature. The process is mediated, in part, by intercellular adhesion molecule-1 (ICAM-1) and results in blood-retinal barrier breakdown and capillary nonperfusion. This study evaluated the expression and function of the corresponding ICAM-1-binding leukocyte beta2-integrins in experimental diabetes.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0146-0404
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
41
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1153-8
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:10752954-Acridine Orange,
pubmed-meshheading:10752954-Animals,
pubmed-meshheading:10752954-Antibodies, Blocking,
pubmed-meshheading:10752954-Antigens, CD18,
pubmed-meshheading:10752954-Cell Adhesion,
pubmed-meshheading:10752954-Diabetes Mellitus, Experimental,
pubmed-meshheading:10752954-Diabetic Retinopathy,
pubmed-meshheading:10752954-Endothelium, Vascular,
pubmed-meshheading:10752954-Flow Cytometry,
pubmed-meshheading:10752954-Lymphocyte Function-Associated Antigen-1,
pubmed-meshheading:10752954-Macrophage-1 Antigen,
pubmed-meshheading:10752954-Neutrophil Activation,
pubmed-meshheading:10752954-Neutrophils,
pubmed-meshheading:10752954-Rats,
pubmed-meshheading:10752954-Rats, Long-Evans,
pubmed-meshheading:10752954-Receptors, Leukocyte-Adhesion,
pubmed-meshheading:10752954-Retinal Vessels,
pubmed-meshheading:10752954-Tumor Necrosis Factor-alpha
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pubmed:year |
2000
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pubmed:articleTitle |
Integrin-mediated neutrophil adhesion and retinal leukostasis in diabetes.
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pubmed:affiliation |
Laboratory for Surgical Research, Children's Hospital, Boston, Massachusetts, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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