Source:http://linkedlifedata.com/resource/pubmed/id/10746978
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
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| pubmed:dateCreated |
2000-5-15
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| pubmed:abstractText |
Tumor progression is angiogenesis dependent, and vascular endothelial growth factor (VEGF) is a key growth factor in this process. sVEGF concentrations in 44 patients with hepatocellular carcinoma (HCC) and 5 with benign liver lesions were determined with an enzyme-link immunoadsorbent assay system (ELISA). Reverse transcript-polymerase chain reaction (RT-PCR) was carried out on surgical specimens of 51 patients with HCC. The relative levels of VEGF mRNA expression were measured by determining a ratio between PCR products of VEGF and the endogenous internal standard gene b-actin. UEA-1 was histochemically used to count microvascularity in tumor tissue. Elevated sVEGF concentrations were found in patients with HCC (172.84+/-111.75 pg/ml) as compared to individuals with benign liver lesions (95.74+/-36.20 pg/ml, P<.05). Of 44 cases with HCC, sVEGF concentrations in the patients with PV-emboli or with poor-encapsulated tumors were significantly higher than in those without PV-emboli or with well-encapsulated tumors (P<0.05). The expression levels of VEGF mRNA in tumors with PV-emboli and in poor-encapsulated tumors were higher than in those without PV-emboli and in well-encapsulated tumors (P<0.05). Microvascular density in HCC tissues was significantly correlated with the expression levels of VEGF mRNA (P<0.01; r=0.7). Circulating VEGF was derived from HCC tissue. sVEGF concentrations could be a new marker for predicting the angiogenesis, invasion and metastasis of HCC.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Endothelial Growth Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Growth Substances,
http://linkedlifedata.com/resource/pubmed/chemical/Lymphokines,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Markers, Biological,
http://linkedlifedata.com/resource/pubmed/chemical/Vascular Endothelial Growth Factor A,
http://linkedlifedata.com/resource/pubmed/chemical/Vascular Endothelial Growth Factors
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| pubmed:status |
MEDLINE
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| pubmed:month |
Dec
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| pubmed:issn |
0392-9078
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
18
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
511-7
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:10746978-Adult,
pubmed-meshheading:10746978-Aged,
pubmed-meshheading:10746978-Carcinoma, Hepatocellular,
pubmed-meshheading:10746978-Endothelial Growth Factors,
pubmed-meshheading:10746978-Female,
pubmed-meshheading:10746978-Growth Substances,
pubmed-meshheading:10746978-Humans,
pubmed-meshheading:10746978-Liver Diseases,
pubmed-meshheading:10746978-Liver Neoplasms,
pubmed-meshheading:10746978-Lymphokines,
pubmed-meshheading:10746978-Male,
pubmed-meshheading:10746978-Middle Aged,
pubmed-meshheading:10746978-Neoplasm Invasiveness,
pubmed-meshheading:10746978-Neoplasm Metastasis,
pubmed-meshheading:10746978-RNA, Messenger,
pubmed-meshheading:10746978-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:10746978-Transcription, Genetic,
pubmed-meshheading:10746978-Tumor Markers, Biological,
pubmed-meshheading:10746978-Vascular Endothelial Growth Factor A,
pubmed-meshheading:10746978-Vascular Endothelial Growth Factors
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| pubmed:year |
1999
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| pubmed:articleTitle |
Serum vascular endothelial growth factor is a predictor of invasion and metastasis in hepatocellular carcinoma.
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| pubmed:affiliation |
Liver Cancer Institute and Zhongshan Hospital, Shanghai Medical University, P.R. China.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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