Source:http://linkedlifedata.com/resource/pubmed/id/10745233
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
2000-7-24
|
| pubmed:abstractText |
The role of GBV-C/HGV in the aetiology of acute non A-E hepatitis and its impact on the course of acute hepatitis of defined aetiology were investigated by detecting viral RNA by RT-PCR and antibody to the E2 protein of GB virus C (anti-E2) by EIA. Ninety-eight patients with acute nonA-E hepatitis, 35 patients with acute hepatitis A, 63 with acute hepatitis B, 29 with acute hepatitis C and 270 controls were enrolled in this study. The prevalence of GBV-C/HGV RNA was similar among patients with acute nonA-E hepatitis (3.1%), with acute hepatitis A (2.9%), and controls (3.7%), but significantly higher (P < 0.05) among those with hepatitis B or C (19.0% and 48.3%, respectively). Similar figures were obtained considering the total rate of GBV-C/HGV exposure (viral RNA or anti-E2 positivity). The majority (24/30 or 80%) of GBV-C/HGV RNA positive patients reported a parenteral source of exposure whereas the remaining 20% denied having known risk factors. The liver function test values and the rate of chronic hepatitis B and C were similar in patients co-infected and in those not co-infected with GBV-C/HGV. This study excludes a significant role of GBV-C/HGV infection in the aetiology of acute nonA-E hepatitis in Italy. Concomitant GBV-C/HGV and HBV or HCV infection does not worsen the clinical course of illness among patients with acute hepatitis.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:status |
MEDLINE
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| pubmed:month |
May
|
| pubmed:issn |
0146-6615
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| pubmed:author | |
| pubmed:copyrightInfo |
Copyright 2000 Wiley-Liss, Inc.
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| pubmed:issnType |
Print
|
| pubmed:volume |
61
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
59-64
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:10745233-Acute Disease,
pubmed-meshheading:10745233-Adolescent,
pubmed-meshheading:10745233-Adult,
pubmed-meshheading:10745233-Aged,
pubmed-meshheading:10745233-Child,
pubmed-meshheading:10745233-Child, Preschool,
pubmed-meshheading:10745233-Female,
pubmed-meshheading:10745233-Flaviviridae,
pubmed-meshheading:10745233-Hepacivirus,
pubmed-meshheading:10745233-Hepatitis,
pubmed-meshheading:10745233-Hepatitis B virus,
pubmed-meshheading:10745233-Hepatovirus,
pubmed-meshheading:10745233-Humans,
pubmed-meshheading:10745233-Infant,
pubmed-meshheading:10745233-Italy,
pubmed-meshheading:10745233-Male,
pubmed-meshheading:10745233-Middle Aged,
pubmed-meshheading:10745233-Questionnaires,
pubmed-meshheading:10745233-Risk Factors
|
| pubmed:year |
2000
|
| pubmed:articleTitle |
GBV-C/hepatitis G virus in acute nonA-E hepatitis and in acute hepatitis of defined aetiology in Italy.
|
| pubmed:affiliation |
Institute of Virology, University of Milan, Milan, Italy.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|