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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2000-4-11
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pubmed:abstractText |
Although whole-body hyperthermia combined with specific genotoxic chemotherapy can be shown to enhance neoplastic cell killing without a concomitant rise in bone marrow toxicity, nephrotoxicity can become treatment-limiting. This study compares the kidney toxicity to the kidney of ifosfamide, carboplatin and etoposide (ICE) chemotherapy alone, and ICE chemotherapy combined with either extracorporeal (e-WBH) or radiant-heat-induced hyperthermia (r-WBH) in 43 patients with refractory sarcoma. Within 3 days of ICE chemotherapy treatment there was a significant increase in urinary protein excretion and a reduction of the glomerular filtration rate. These effects were more pronounced if WBH was added. The use of immunoluminometric assays revealed a predominance of low-molecular-mass proteins. This increase in protein excretion persisted in the e-WBH-treated group, whereas it vanished within 3 weeks in both the group treated with ICE alone and that treated with r-WBH. Our findings suggest that ICE chemotherapy causes transient tubular and glomerular damage, which is enhanced by WBH. In terms of long-term nephrotoxicity e-WBH was more nephrotoxic than r-WBH. This finding is consistent with our clinical observations.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents, Alkylating,
http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents, Phytogenic,
http://linkedlifedata.com/resource/pubmed/chemical/Carboplatin,
http://linkedlifedata.com/resource/pubmed/chemical/Creatinine,
http://linkedlifedata.com/resource/pubmed/chemical/Etoposide,
http://linkedlifedata.com/resource/pubmed/chemical/Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Ifosfamide,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin G,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/SPINT2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Trypsin Inhibitor, Kunitz Soybean
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0171-5216
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
126
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
173-7
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:10741912-Adolescent,
pubmed-meshheading:10741912-Adult,
pubmed-meshheading:10741912-Aged,
pubmed-meshheading:10741912-Albuminuria,
pubmed-meshheading:10741912-Antineoplastic Agents, Alkylating,
pubmed-meshheading:10741912-Antineoplastic Agents, Phytogenic,
pubmed-meshheading:10741912-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:10741912-Carboplatin,
pubmed-meshheading:10741912-Clinical Trials, Phase II as Topic,
pubmed-meshheading:10741912-Creatinine,
pubmed-meshheading:10741912-Etoposide,
pubmed-meshheading:10741912-Female,
pubmed-meshheading:10741912-Glomerular Filtration Rate,
pubmed-meshheading:10741912-Glycoproteins,
pubmed-meshheading:10741912-Humans,
pubmed-meshheading:10741912-Hyperthermia, Induced,
pubmed-meshheading:10741912-Ifosfamide,
pubmed-meshheading:10741912-Immunoglobulin G,
pubmed-meshheading:10741912-Kidney,
pubmed-meshheading:10741912-Male,
pubmed-meshheading:10741912-Membrane Glycoproteins,
pubmed-meshheading:10741912-Middle Aged,
pubmed-meshheading:10741912-Sarcoma,
pubmed-meshheading:10741912-Trypsin Inhibitor, Kunitz Soybean
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pubmed:year |
2000
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pubmed:articleTitle |
Nephrotoxicity of ifosfamide, carboplatin and etoposide (ICE) alone or combined with extracorporeal or radiant-heat-induced whole-body hyperthermia.
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pubmed:affiliation |
Department of Internal Medicine I, Medical University of Lübeck, Germany. gerke@hotmail.com
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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