| pubmed-article:10741712 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10741712 | lifeskim:mentions | umls-concept:C0684249 | lld:lifeskim |
| pubmed-article:10741712 | lifeskim:mentions | umls-concept:C0334227 | lld:lifeskim |
| pubmed-article:10741712 | lifeskim:mentions | umls-concept:C0041904 | lld:lifeskim |
| pubmed-article:10741712 | lifeskim:mentions | umls-concept:C0079419 | lld:lifeskim |
| pubmed-article:10741712 | lifeskim:mentions | umls-concept:C0162493 | lld:lifeskim |
| pubmed-article:10741712 | lifeskim:mentions | umls-concept:C1547239 | lld:lifeskim |
| pubmed-article:10741712 | lifeskim:mentions | umls-concept:C1517499 | lld:lifeskim |
| pubmed-article:10741712 | lifeskim:mentions | umls-concept:C0127400 | lld:lifeskim |
| pubmed-article:10741712 | lifeskim:mentions | umls-concept:C1363844 | lld:lifeskim |
| pubmed-article:10741712 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:10741712 | pubmed:dateCreated | 2000-6-1 | lld:pubmed |
| pubmed-article:10741712 | pubmed:abstractText | Overexpression of wild-type p53 in cancer cells by adenovirus-mediated p53 gene transfer can result in the induction of apoptosis. To identify the potential mediators of this p53-induced apoptosis, we examined apoptotic protein levels in human lung cancer cells after Adp53 gene transfer. We observed up-regulation of Bax and Bak protein levels 18-36 h after transduction with Adp53 in H1299, H358, and H322 lung cancer cells. Contrary to expected observations, no changes in Bcl-2 and Bcl-X(L) protein levels were observed. Morphological cell changes and terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling staining showed evidence of apoptosis in all cell lines 48 h after transduction with Adp53. These results indicate that the induction of apoptosis by adenovirus-mediated p53 transfer may be mediated by the induction of proapoptotic mechanisms rather than suppression of antiapoptotic mechanisms. | lld:pubmed |
| pubmed-article:10741712 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10741712 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10741712 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10741712 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10741712 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10741712 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10741712 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10741712 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10741712 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10741712 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10741712 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10741712 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10741712 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10741712 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10741712 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10741712 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10741712 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10741712 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10741712 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:10741712 | pubmed:issn | 1078-0432 | lld:pubmed |
| pubmed-article:10741712 | pubmed:author | pubmed-author:RothJ AJA | lld:pubmed |
| pubmed-article:10741712 | pubmed:author | pubmed-author:MeynR ERE | lld:pubmed |
| pubmed-article:10741712 | pubmed:author | pubmed-author:KataokaMM | lld:pubmed |
| pubmed-article:10741712 | pubmed:author | pubmed-author:McDonnellT... | lld:pubmed |
| pubmed-article:10741712 | pubmed:author | pubmed-author:SwisherS GSG | lld:pubmed |
| pubmed-article:10741712 | pubmed:author | pubmed-author:CristianoR... | lld:pubmed |
| pubmed-article:10741712 | pubmed:author | pubmed-author:PearsonA SAS | lld:pubmed |
| pubmed-article:10741712 | pubmed:author | pubmed-author:StarrC GCG | lld:pubmed |
| pubmed-article:10741712 | pubmed:author | pubmed-author:SarkissM GMG | lld:pubmed |
| pubmed-article:10741712 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10741712 | pubmed:volume | 6 | lld:pubmed |
| pubmed-article:10741712 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10741712 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10741712 | pubmed:pagination | 887-90 | lld:pubmed |
| pubmed-article:10741712 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:10741712 | pubmed:meshHeading | pubmed-meshheading:10741712... | lld:pubmed |
| pubmed-article:10741712 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10741712 | pubmed:articleTitle | Up-regulation of the proapoptotic mediators Bax and Bak after adenovirus-mediated p53 gene transfer in lung cancer cells. | lld:pubmed |
| pubmed-article:10741712 | pubmed:affiliation | Department of Surgical Oncology, The University of Texas M.D Anderson Cancer Center, Houston 77030, USA. | lld:pubmed |
| pubmed-article:10741712 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10741712 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:10741712 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10741712 | lld:pubmed |
