Linked Life Data

10728718

Source:http://linkedlifedata.com/resource/pubmed/id/10728718

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2000-4-19
pubmed:abstractText
This paper reviews the six published incidence studies of the relative risk of cancer in patients with schizophrenia compared with the general population. These studies used: incidence data, register case ascertainment, and controlled for age and sex. It is concluded that schizophrenia is associated with a lower risk of developing cancer. The role of apoptosis (programmed cell death) in cancer and brain development is briefly described. The possibility is explored that increased apoptosis may account for neurodevelopmental abnormalities as well as tumour resistance associated with schizophrenia. The authors propose that p53, a tumour suppressor gene central to regulation of apoptosis, should be investigated as a candidate susceptibility gene in schizophrenia.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0920-9964
pubmed:author
pubmed:issnType
Print
pubmed:day
14
pubmed:volume
41
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
405-15
pubmed:dateRevised
2010-9-2
pubmed:meshHeading
pubmed:year
2000
pubmed:articleTitle
Apoptosis and schizophrenia: is the tumour suppressor gene, p53, a candidate susceptibility gene?
pubmed:affiliation
Schizophrenia Research Unit, South Western Sydney Area Health Service, Liverpool Hospital, Liverpool, NSW, Australia.
pubmed:publicationType
Journal Article, Review