| pubmed-article:107261 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:107261 | lifeskim:mentions | umls-concept:C0003241 | lld:lifeskim |
| pubmed-article:107261 | lifeskim:mentions | umls-concept:C1521761 | lld:lifeskim |
| pubmed-article:107261 | lifeskim:mentions | umls-concept:C0205369 | lld:lifeskim |
| pubmed-article:107261 | lifeskim:mentions | umls-concept:C0439605 | lld:lifeskim |
| pubmed-article:107261 | lifeskim:mentions | umls-concept:C1522138 | lld:lifeskim |
| pubmed-article:107261 | lifeskim:mentions | umls-concept:C0038857 | lld:lifeskim |
| pubmed-article:107261 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:107261 | pubmed:dateCreated | 1979-6-11 | lld:pubmed |
| pubmed-article:107261 | pubmed:abstractText | T-cell derived suppressor factors (TsF) specific for the random copolymers L-glutamic acid60-L-alanine30-Ltyrosine10 and L-glutamic acid60-L-alanine40, referred to as GAT and GA, respectively, were prepared and partially purified on the approprate antigen immunoadsorbents. GAT-TsF obtained from nonresponder DBA/1 (H-2q) and SJL (H-2s) mice were passed over immunoadsorbents prepared from normal guinea pig serum (NGPS) or guinea pig anti-idiotype antiserum (anti-CGAT) specific for a common cross-reactive idiotype found on most anti-GAT antibodies in all mouse strains tested. Both the directly suppressive activity of the GAT-TsF and the ability of GAT-TsF to induce new suppressor T cells (Ts2) in vitro were adsorbed to and fully recoverable from the guinea pig anti-CGAT-Sepharose immunoadsorbent, while the TsF passed through the control NGPS-Sepharose without appreciable binding. The SJL GAT-TsF specifically eluted from anti-CGAT-immunoadsrobents was shown to still posses I-J determinants. These data provide evidence suggesting a sharing of V region structures between B-cell antibody and T-cell suppressor factor specific for an antigen (GAT) under Ir gene control, in agreement with earlier studies on T and B-cell alloreceptors, T-cell helper factors, and T and B-cell receptors for conventional antigens. | lld:pubmed |
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| pubmed-article:107261 | pubmed:language | eng | lld:pubmed |
| pubmed-article:107261 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:107261 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:107261 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:107261 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:107261 | pubmed:issn | 0022-1007 | lld:pubmed |
| pubmed-article:107261 | pubmed:author | pubmed-author:BenacerrafBB | lld:pubmed |
| pubmed-article:107261 | pubmed:author | pubmed-author:DorfM EME | lld:pubmed |
| pubmed-article:107261 | pubmed:author | pubmed-author:OSEMM | lld:pubmed |
| pubmed-article:107261 | pubmed:author | pubmed-author:GermainR NRN | lld:pubmed |
| pubmed-article:107261 | pubmed:author | pubmed-author:KippsT JTJ | lld:pubmed |
| pubmed-article:107261 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:107261 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:107261 | pubmed:volume | 149 | lld:pubmed |
| pubmed-article:107261 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:107261 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:107261 | pubmed:pagination | 613-22 | lld:pubmed |
| pubmed-article:107261 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:107261 | pubmed:year | 1979 | lld:pubmed |
| pubmed-article:107261 | pubmed:articleTitle | Shared idiotypic determinants on antibodies and T-cell-derived suppressor factor specific for the random terpolymer L-glutamic acid60-L-alanine30-L-tyrosine10. | lld:pubmed |
| pubmed-article:107261 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:107261 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:107261 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
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