Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1979-6-11
pubmed:abstractText
T-cell derived suppressor factors (TsF) specific for the random copolymers L-glutamic acid60-L-alanine30-Ltyrosine10 and L-glutamic acid60-L-alanine40, referred to as GAT and GA, respectively, were prepared and partially purified on the approprate antigen immunoadsorbents. GAT-TsF obtained from nonresponder DBA/1 (H-2q) and SJL (H-2s) mice were passed over immunoadsorbents prepared from normal guinea pig serum (NGPS) or guinea pig anti-idiotype antiserum (anti-CGAT) specific for a common cross-reactive idiotype found on most anti-GAT antibodies in all mouse strains tested. Both the directly suppressive activity of the GAT-TsF and the ability of GAT-TsF to induce new suppressor T cells (Ts2) in vitro were adsorbed to and fully recoverable from the guinea pig anti-CGAT-Sepharose immunoadsorbent, while the TsF passed through the control NGPS-Sepharose without appreciable binding. The SJL GAT-TsF specifically eluted from anti-CGAT-immunoadsrobents was shown to still posses I-J determinants. These data provide evidence suggesting a sharing of V region structures between B-cell antibody and T-cell suppressor factor specific for an antigen (GAT) under Ir gene control, in agreement with earlier studies on T and B-cell alloreceptors, T-cell helper factors, and T and B-cell receptors for conventional antigens.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/107261-137363, http://linkedlifedata.com/resource/pubmed/commentcorrection/107261-282636, http://linkedlifedata.com/resource/pubmed/commentcorrection/107261-300776, http://linkedlifedata.com/resource/pubmed/commentcorrection/107261-307689, http://linkedlifedata.com/resource/pubmed/commentcorrection/107261-322367, http://linkedlifedata.com/resource/pubmed/commentcorrection/107261-4126766, http://linkedlifedata.com/resource/pubmed/commentcorrection/107261-413058, http://linkedlifedata.com/resource/pubmed/commentcorrection/107261-418136, http://linkedlifedata.com/resource/pubmed/commentcorrection/107261-55436, http://linkedlifedata.com/resource/pubmed/commentcorrection/107261-56419, http://linkedlifedata.com/resource/pubmed/commentcorrection/107261-67171, http://linkedlifedata.com/resource/pubmed/commentcorrection/107261-690432, http://linkedlifedata.com/resource/pubmed/commentcorrection/107261-71240, http://linkedlifedata.com/resource/pubmed/commentcorrection/107261-75231, http://linkedlifedata.com/resource/pubmed/commentcorrection/107261-768405
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0022-1007
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
149
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
613-22
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1979
pubmed:articleTitle
Shared idiotypic determinants on antibodies and T-cell-derived suppressor factor specific for the random terpolymer L-glutamic acid60-L-alanine30-L-tyrosine10.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S.