rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1979-6-11
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pubmed:abstractText |
T-cell derived suppressor factors (TsF) specific for the random copolymers L-glutamic acid60-L-alanine30-Ltyrosine10 and L-glutamic acid60-L-alanine40, referred to as GAT and GA, respectively, were prepared and partially purified on the approprate antigen immunoadsorbents. GAT-TsF obtained from nonresponder DBA/1 (H-2q) and SJL (H-2s) mice were passed over immunoadsorbents prepared from normal guinea pig serum (NGPS) or guinea pig anti-idiotype antiserum (anti-CGAT) specific for a common cross-reactive idiotype found on most anti-GAT antibodies in all mouse strains tested. Both the directly suppressive activity of the GAT-TsF and the ability of GAT-TsF to induce new suppressor T cells (Ts2) in vitro were adsorbed to and fully recoverable from the guinea pig anti-CGAT-Sepharose immunoadsorbent, while the TsF passed through the control NGPS-Sepharose without appreciable binding. The SJL GAT-TsF specifically eluted from anti-CGAT-immunoadsrobents was shown to still posses I-J determinants. These data provide evidence suggesting a sharing of V region structures between B-cell antibody and T-cell suppressor factor specific for an antigen (GAT) under Ir gene control, in agreement with earlier studies on T and B-cell alloreceptors, T-cell helper factors, and T and B-cell receptors for conventional antigens.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/107261-137363,
http://linkedlifedata.com/resource/pubmed/commentcorrection/107261-282636,
http://linkedlifedata.com/resource/pubmed/commentcorrection/107261-300776,
http://linkedlifedata.com/resource/pubmed/commentcorrection/107261-307689,
http://linkedlifedata.com/resource/pubmed/commentcorrection/107261-322367,
http://linkedlifedata.com/resource/pubmed/commentcorrection/107261-4126766,
http://linkedlifedata.com/resource/pubmed/commentcorrection/107261-413058,
http://linkedlifedata.com/resource/pubmed/commentcorrection/107261-418136,
http://linkedlifedata.com/resource/pubmed/commentcorrection/107261-55436,
http://linkedlifedata.com/resource/pubmed/commentcorrection/107261-56419,
http://linkedlifedata.com/resource/pubmed/commentcorrection/107261-67171,
http://linkedlifedata.com/resource/pubmed/commentcorrection/107261-690432,
http://linkedlifedata.com/resource/pubmed/commentcorrection/107261-71240,
http://linkedlifedata.com/resource/pubmed/commentcorrection/107261-75231,
http://linkedlifedata.com/resource/pubmed/commentcorrection/107261-768405
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pubmed:language |
eng
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pubmed:journal |
|
pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0022-1007
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pubmed:author |
|
pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
149
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
613-22
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:107261-Alanine,
pubmed-meshheading:107261-Animals,
pubmed-meshheading:107261-Antibodies,
pubmed-meshheading:107261-Genes, MHC Class II,
pubmed-meshheading:107261-Glutamates,
pubmed-meshheading:107261-Immunoglobulin Idiotypes,
pubmed-meshheading:107261-Immunosorbent Techniques,
pubmed-meshheading:107261-Immunosuppression,
pubmed-meshheading:107261-Mice,
pubmed-meshheading:107261-Mice, Inbred Strains,
pubmed-meshheading:107261-Peptides,
pubmed-meshheading:107261-T-Lymphocytes,
pubmed-meshheading:107261-Tyrosine
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pubmed:year |
1979
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pubmed:articleTitle |
Shared idiotypic determinants on antibodies and T-cell-derived suppressor factor specific for the random terpolymer L-glutamic acid60-L-alanine30-L-tyrosine10.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.
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