| pubmed-article:10725702 | rdf:type | pubmed:Citation | lld:pubmed |
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| pubmed-article:10725702 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:10725702 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:10725702 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:10725702 | lifeskim:mentions | umls-concept:C1413243 | lld:lifeskim |
| pubmed-article:10725702 | lifeskim:mentions | umls-concept:C1424497 | lld:lifeskim |
| pubmed-article:10725702 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:10725702 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:10725702 | lifeskim:mentions | umls-concept:C0547047 | lld:lifeskim |
| pubmed-article:10725702 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:10725702 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:10725702 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:10725702 | pubmed:dateCreated | 2000-5-4 | lld:pubmed |
| pubmed-article:10725702 | pubmed:abstractText | These studies were performed to establish whether functional receptors for calcitonin gene-related peptide (CGRP) are present on human dendritic cells (DCs) and to investigate potential immunomodulatory effects of CGRP on DCs other than Langerhans cells. Reverse transcriptase-PCR revealed expression of mRNA for a type 1 CGRP receptor by mature and immature blood-derived DCs. Sequence analysis confirmed the identity of the type 1 CGRP receptor (CGRP-R1). Addition of CGRP (10-7 M) to mature and immature DCs resulted in mobilization of intracellular calcium. Treatment of immature DCs with CGRP (10-7 M), before and after maturation in monocyte-conditioned medium, resulted in decreased cell surface expression of HLA-DR MHC class II and the costimulatory molecule, CD86. Treatment of immature DCs with CGRP (10-7 M) also resulted in decreased expression of CD86, but expression of HLA-DR was unchanged. When CGRP-treated mature DCs were used to stimulate allogeneic T cells, proliferative responses were dampened (approximately 50%), especially at low DC:T cell ratios (1:360). This effect was not observed with CGRP-treated, immature DCs. In contrast, CGRP-treated mature or immature DCs were no less efficient than untreated DCs in driving syngeneic T cell-proliferative responses to staphylococcal enterotoxin B. We conclude that mature and immature DCs express type 1 CGRP receptors and that signaling through these receptors may dampen mature DC-driven T cell proliferation most likely via down-regulation of CD86 and HLA-DR. | lld:pubmed |
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| pubmed-article:10725702 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10725702 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10725702 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:10725702 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10725702 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:10725702 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:10725702 | pubmed:author | pubmed-author:PopeMM | lld:pubmed |
| pubmed-article:10725702 | pubmed:author | pubmed-author:SteinmanR MRM | lld:pubmed |
| pubmed-article:10725702 | pubmed:author | pubmed-author:WeiYY | lld:pubmed |
| pubmed-article:10725702 | pubmed:author | pubmed-author:MojsovSS | lld:pubmed |
| pubmed-article:10725702 | pubmed:author | pubmed-author:CypessA MAM | lld:pubmed |
| pubmed-article:10725702 | pubmed:author | pubmed-author:CarucciJ AJA | lld:pubmed |
| pubmed-article:10725702 | pubmed:author | pubmed-author:IgnatiusRR | lld:pubmed |
| pubmed-article:10725702 | pubmed:author | pubmed-author:SchaerD ADA | lld:pubmed |
| pubmed-article:10725702 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10725702 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:10725702 | pubmed:volume | 164 | lld:pubmed |
| pubmed-article:10725702 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10725702 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10725702 | pubmed:pagination | 3494-9 | lld:pubmed |
| pubmed-article:10725702 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:10725702 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10725702 | pubmed:articleTitle | Calcitonin gene-related peptide decreases expression of HLA-DR and CD86 by human dendritic cells and dampens dendritic cell-driven T cell-proliferative responses via the type I calcitonin gene-related peptide receptor. | lld:pubmed |
| pubmed-article:10725702 | pubmed:affiliation | Laboratories of Cellular Physiology Rockefeller University, New York, NY 10021, USA. | lld:pubmed |
| pubmed-article:10725702 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10725702 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:10725702 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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