Source:http://linkedlifedata.com/resource/pubmed/id/10719760
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
2000-3-28
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| pubmed:abstractText |
To determine if the aging-associated decline in testosterone results in attenuated vasopressin (VP) responses to dehydration, testosterone implants were given to aged male Fischer 344Brown-Norway F1(F344BNF1) rats. Water deprivation caused comparable dehydration, increased plasma VP (pVP), and decreased posterior pituitary (PP) VP content in 4-, 15-, and 28-month-old rats. Dehydration increased VP mRNA content of supraoptic nuclei only at 4 months, whereas VP mRNA length was increased at both 4 and 15 months of age. The elevated pVP in the water-deprived aged rats indicates that even without an increase in VP mRNA content, PP VP storage was adequate to maintain elevated pVP. Dehydration increased aquaporin-2 content at 4, but not at 15 or 28 months of age, suggesting decreased renal responsiveness to VP. Testosterone replacement did not produce dehydration-induced increases in VP mRNA or aquaporin-2. Therefore, testosterone deficiency does not result in altered VP responses to dehydration in aged F344BNF1 rats.
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| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Aquaporins,
http://linkedlifedata.com/resource/pubmed/chemical/Drug Implants,
http://linkedlifedata.com/resource/pubmed/chemical/Progesterone,
http://linkedlifedata.com/resource/pubmed/chemical/RNA,
http://linkedlifedata.com/resource/pubmed/chemical/Testosterone,
http://linkedlifedata.com/resource/pubmed/chemical/Vasopressins
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| pubmed:status |
MEDLINE
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| pubmed:month |
Jan
|
| pubmed:issn |
1079-5006
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
55
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
B26-34
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| pubmed:dateRevised |
2007-11-14
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| pubmed:meshHeading |
pubmed-meshheading:10719760-Aging,
pubmed-meshheading:10719760-Analysis of Variance,
pubmed-meshheading:10719760-Animals,
pubmed-meshheading:10719760-Aquaporins,
pubmed-meshheading:10719760-Blotting, Northern,
pubmed-meshheading:10719760-Blotting, Western,
pubmed-meshheading:10719760-Dehydration,
pubmed-meshheading:10719760-Drug Implants,
pubmed-meshheading:10719760-Kidney Medulla,
pubmed-meshheading:10719760-Male,
pubmed-meshheading:10719760-Pituitary Gland, Posterior,
pubmed-meshheading:10719760-Progesterone,
pubmed-meshheading:10719760-RNA,
pubmed-meshheading:10719760-Radioimmunoassay,
pubmed-meshheading:10719760-Rats,
pubmed-meshheading:10719760-Rats, Inbred BN,
pubmed-meshheading:10719760-Rats, Inbred F344,
pubmed-meshheading:10719760-Testosterone,
pubmed-meshheading:10719760-Vasopressins
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| pubmed:year |
2000
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| pubmed:articleTitle |
Effect of age and testosterone on the vasopressin and aquaporin responses to dehydration in Fischer 344/Brown-Norway F1 rats.
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| pubmed:affiliation |
Department of Physiology and Biophysics, Finch University of Health Sciences/The Chicago Medical School, North Chicago, Illinois 60064, USA.
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| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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