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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2000-4-7
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pubmed:abstractText |
A new concept is the intensification of preparative regimens for patients with advanced leukemia using monoclonal antibodies (MAbs) with an affinity for beta emitter-labeled bone marrow. 188Re is a high-energy beta emitter that has therapeutic promise. Our first aim was to clarify whether the therapeutic application of 188Re-MAb against nonspecific cross-reacting antigen 95 (NCA-95) can be predicted from biokinetic data derived from 99mTc-labeled NCA-95. Our second aim was to show that a radiation absorbed dose of > or =12 Gy in the bone marrow can be achieved using 188Re-MAb.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0161-5505
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
41
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
531-7
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pubmed:dateRevised |
2005-11-21
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pubmed:meshHeading |
pubmed-meshheading:10716329-Adult,
pubmed-meshheading:10716329-Antibodies, Monoclonal,
pubmed-meshheading:10716329-Antigens, Neoplasm,
pubmed-meshheading:10716329-Cell Adhesion Molecules,
pubmed-meshheading:10716329-Female,
pubmed-meshheading:10716329-Hematopoietic Stem Cell Transplantation,
pubmed-meshheading:10716329-Humans,
pubmed-meshheading:10716329-Leukemia,
pubmed-meshheading:10716329-Male,
pubmed-meshheading:10716329-Membrane Glycoproteins,
pubmed-meshheading:10716329-Middle Aged,
pubmed-meshheading:10716329-Phantoms, Imaging,
pubmed-meshheading:10716329-Radioimmunotherapy,
pubmed-meshheading:10716329-Radiometry,
pubmed-meshheading:10716329-Rhenium,
pubmed-meshheading:10716329-Technetium,
pubmed-meshheading:10716329-Tissue Distribution,
pubmed-meshheading:10716329-Transplantation Conditioning
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pubmed:year |
2000
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pubmed:articleTitle |
Radioimmunotherapy for the intensification of conditioning before stem cell transplantation: differences in dosimetry and biokinetics of 188Re- and 99mTc-labeled anti-NCA-95 MAbs.
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pubmed:affiliation |
Department of Nuclear Medicine, University Ulm, Germany.
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pubmed:publicationType |
Journal Article
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