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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2000-5-19
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pubmed:abstractText |
B-1 cells differ from conventional peripheral B cells (B-2) by anatomical location, surface marker expression, antibody repertoire and growth properties. The lineage hypothesis of B-1 cell development attributes the properties of B-1 cells to their unique origin. The induced differentiation hypothesis suggests the surface-immunoglobulin-driven development of B-1 cells from common B-1/B-2 cell progenitors. In both models self-antigen-induced signalling plays the central role in positive selection of B-1 cells. The ability of B-1 cells to be positively selected by self-antigens raises questions about the mechanism of this phenomenon.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD5,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation...,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Thy-1,
http://linkedlifedata.com/resource/pubmed/chemical/Autoantibodies,
http://linkedlifedata.com/resource/pubmed/chemical/Autoantigens,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin Heavy Chains,
http://linkedlifedata.com/resource/pubmed/chemical/Phorbol Esters,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Antigen, B-Cell
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0952-7915
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
12
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
191-4
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:10712945-Animals,
pubmed-meshheading:10712945-Antigens, CD5,
pubmed-meshheading:10712945-Antigens, Differentiation, B-Lymphocyte,
pubmed-meshheading:10712945-Antigens, Thy-1,
pubmed-meshheading:10712945-Autoantibodies,
pubmed-meshheading:10712945-Autoantigens,
pubmed-meshheading:10712945-Autoimmunity,
pubmed-meshheading:10712945-B-Lymphocyte Subsets,
pubmed-meshheading:10712945-Cell Differentiation,
pubmed-meshheading:10712945-Cell Lineage,
pubmed-meshheading:10712945-Clonal Deletion,
pubmed-meshheading:10712945-Gene Rearrangement, B-Lymphocyte, Heavy Chain,
pubmed-meshheading:10712945-Hematopoietic Stem Cells,
pubmed-meshheading:10712945-Humans,
pubmed-meshheading:10712945-Immunoglobulin Heavy Chains,
pubmed-meshheading:10712945-Lymphocyte Activation,
pubmed-meshheading:10712945-Mice,
pubmed-meshheading:10712945-Mice, Transgenic,
pubmed-meshheading:10712945-Models, Immunological,
pubmed-meshheading:10712945-Phorbol Esters,
pubmed-meshheading:10712945-Receptors, Antigen, B-Cell,
pubmed-meshheading:10712945-Signal Transduction
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pubmed:year |
2000
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pubmed:articleTitle |
B-1 cells: orthodox or conformist?
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pubmed:affiliation |
Laboratory of Lymphocyte Signaling, Institute for Genetics, University of Köln, Köln, D-50931, Germany.
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pubmed:publicationType |
Journal Article,
Review,
Research Support, Non-U.S. Gov't
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