| pubmed-article:10709107 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10709107 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:10709107 | lifeskim:mentions | umls-concept:C0338106 | lld:lifeskim |
| pubmed-article:10709107 | lifeskim:mentions | umls-concept:C1510779 | lld:lifeskim |
| pubmed-article:10709107 | lifeskim:mentions | umls-concept:C0021701 | lld:lifeskim |
| pubmed-article:10709107 | lifeskim:mentions | umls-concept:C0003241 | lld:lifeskim |
| pubmed-article:10709107 | lifeskim:mentions | umls-concept:C0205281 | lld:lifeskim |
| pubmed-article:10709107 | lifeskim:mentions | umls-concept:C0085732 | lld:lifeskim |
| pubmed-article:10709107 | lifeskim:mentions | umls-concept:C0232901 | lld:lifeskim |
| pubmed-article:10709107 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:10709107 | lifeskim:mentions | umls-concept:C2349975 | lld:lifeskim |
| pubmed-article:10709107 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:10709107 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:10709107 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:10709107 | pubmed:dateCreated | 2000-3-23 | lld:pubmed |
| pubmed-article:10709107 | pubmed:abstractText | Integrin-mediated adhesion of cells to extracellular matrix proteins has been shown to activate various intracellular signaling events. In the present study, we demonstrate that the addition of a monoclonal antibody raised against the beta4 integrin subunit in the culture medium of a clone derived from the colon adenocarcinoma cell line LoVo specifically results in stimulation of cell migration and invasion through reconstituted basement membrane matrices. Moreover, an increase in MMP-2 activity is observed. Conversely, monoclonal anti-alpha6 and anti-beta1 have no effect on MMP-2 expression. The s. c. co-injection of adenocarcinoma cells with antibodies raised against the beta4 integrin subunit to immunosuppressed newborn rats gives rise to tumors displaying altered and disorganized peri-tumoral basement membranes compared with tumors obtained when cells are injected with adenocarcinoma cells alone. Higher metastatic capacity of cells results when they are co-injected with antibodies to the beta4 integrin subunit. Our results suggest that the beta4 subunit of alpha6beta4 integrin, a laminin receptor in colon adenocarcinoma, may be responsible for the specific signals which stimulate cell motility, expression of MMP-2 and tumor invasion. | lld:pubmed |
| pubmed-article:10709107 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10709107 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10709107 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10709107 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10709107 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10709107 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10709107 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:10709107 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10709107 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10709107 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:10709107 | pubmed:issn | 0020-7136 | lld:pubmed |
| pubmed-article:10709107 | pubmed:author | pubmed-author:ChayvialleJ... | lld:pubmed |
| pubmed-article:10709107 | pubmed:author | pubmed-author:RemsJJ | lld:pubmed |
| pubmed-article:10709107 | pubmed:author | pubmed-author:LissitzkyJ... | lld:pubmed |
| pubmed-article:10709107 | pubmed:author | pubmed-author:ThomassenHH | lld:pubmed |
| pubmed-article:10709107 | pubmed:author | pubmed-author:JacquierM FMF | lld:pubmed |
| pubmed-article:10709107 | pubmed:author | pubmed-author:RoussellePP | lld:pubmed |
| pubmed-article:10709107 | pubmed:author | pubmed-author:DaemsDD | lld:pubmed |
| pubmed-article:10709107 | pubmed:author | pubmed-author:DumortierJJ | lld:pubmed |
| pubmed-article:10709107 | pubmed:author | pubmed-author:PourreyronCC | lld:pubmed |
| pubmed-article:10709107 | pubmed:copyrightInfo | Copyright 2000 Wiley-Liss, Inc. | lld:pubmed |
| pubmed-article:10709107 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10709107 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:10709107 | pubmed:volume | 85 | lld:pubmed |
| pubmed-article:10709107 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10709107 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10709107 | pubmed:pagination | 850-6 | lld:pubmed |
| pubmed-article:10709107 | pubmed:dateRevised | 2007-7-24 | lld:pubmed |
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| pubmed-article:10709107 | pubmed:meshHeading | pubmed-meshheading:10709107... | lld:pubmed |
| pubmed-article:10709107 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10709107 | pubmed:articleTitle | Anti-beta4 integrin antibodies enhance migratory and invasive abilities of human colon adenocarcinoma cells and their MMP-2 expression. | lld:pubmed |
| pubmed-article:10709107 | pubmed:affiliation | INSERM U 45, Hôpital Edouard Herriot, Lyon, France. | lld:pubmed |
| pubmed-article:10709107 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10709107 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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