Source:http://linkedlifedata.com/resource/pubmed/id/10706444
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3-4
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pubmed:dateCreated |
2000-3-24
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pubmed:abstractText |
To produce antibodies, the differentiation of B cells into antibody-secreting cells, plasma cells, is required. We describe that ligation of CD27, which belongs to the tumor necrosis factor receptor (TNFR) family and is a memory marker of B cells, yields crucial signals that positively control the entry of B cells into the pathway to plasma cells. The triggering via CD27 by CD27 ligand (CD70) on purified peripheral blood B cells yielded an increase in the number of plasma cells in the presence of interleukin-10 (IL-10). The differentiation into plasma cells by a combination of IL-10 and CD70-transfectants occurred in CD27+ B cells, but not in CD27- B cells. Moreover, the addition of IL-2 to the IL-10 and CD70-transfectants greatly induced the differentiation into plasma cells. In the presence of only IL-2, IL-4 or IL-6, CD70-transfectants did not promote the differentiation into plasma cells. On the other hand, CD40 signaling increased the expansion of a B cell pool from peripheral blood B cells primarily activated by IL-2, IL-10 and anti-CD40 mAb. These data demonstrate that CD27 ligand (CD70) is a key molecule to direct the differentiation of CD27+ memory B cells toward plasma cells in cooperation with IL-10.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD27,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD70,
http://linkedlifedata.com/resource/pubmed/chemical/CD70 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1042-8194
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
35
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
219-25
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pubmed:dateRevised |
2008-5-14
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pubmed:meshHeading |
pubmed-meshheading:10706444-Animals,
pubmed-meshheading:10706444-Antigens, CD,
pubmed-meshheading:10706444-Antigens, CD27,
pubmed-meshheading:10706444-Antigens, CD70,
pubmed-meshheading:10706444-B-Lymphocytes,
pubmed-meshheading:10706444-Cell Differentiation,
pubmed-meshheading:10706444-Humans,
pubmed-meshheading:10706444-Membrane Proteins,
pubmed-meshheading:10706444-Plasma Cells,
pubmed-meshheading:10706444-Signal Transduction
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pubmed:year |
1999
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pubmed:articleTitle |
Plasma cell generation from B-lymphocytes via CD27/CD70 interaction.
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pubmed:affiliation |
From the Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Japan. agemats@gipac.shinshu-u.ac.jp
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pubmed:publicationType |
Journal Article,
Review
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