Linked Life Data

10704997

Source:http://linkedlifedata.com/resource/pubmed/id/10704997

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2000-6-19
pubmed:abstractText
Wind-up is a frequency-dependent increase in the excitability of spinal cord neurones, evoked by electrical stimulation of afferent C-fibres. Although it has been studied over the past thirty years, there are still uncertainties about its physiological meaning. Glutamate (NMDA) and tachykinin NK1 receptors are required to generate wind-up and therefore a positive modulation between these two receptor types has been suggested by some authors. However, most drugs capable of reducing the excitability of spinal cord neurones, including opioids and NSAIDs, can also reduce or even abolish wind-up. Thus, other theories involving synaptic efficacy, potassium channels, calcium channels, etc. have also been proposed for the generation of this phenomenon. Whatever the mechanisms involved in its generation, wind-up has been interpreted as a system for the amplification in the spinal cord of the nociceptive message that arrives from peripheral nociceptors connected to C-fibres. This probably reflects the physiological system activated in the spinal cord after an intense or persistent barrage of afferent nociceptive impulses. On the other hand, wind-up, central sensitisation and hyperalgesia are not the same phenomena, although they may share common properties. Wind-up can be an important tool to study the processing of nociceptive information in the spinal cord, and the central effects of drugs that modulate the nociceptive system. This paper reviews the physiological and pharmacological data on wind-up of spinal cord neurones, and the perceptual correlates of wind-up in human subjects, in the context of its possible relation to the triggering of hyperalgesic states, and also the multiple factors which contribute to the generation of wind-up.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0301-0082
pubmed:author
pubmed:issnType
Print
pubmed:volume
61
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
169-203
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:10704997-Afferent Pathways, pubmed-meshheading:10704997-Analgesics, pubmed-meshheading:10704997-Anesthetics, Local, pubmed-meshheading:10704997-Animals, pubmed-meshheading:10704997-Anti-Inflammatory Agents, Non-Steroidal, pubmed-meshheading:10704997-Cats, pubmed-meshheading:10704997-Humans, pubmed-meshheading:10704997-Hyperalgesia, pubmed-meshheading:10704997-Inflammation, pubmed-meshheading:10704997-Ion Transport, pubmed-meshheading:10704997-Models, Neurological, pubmed-meshheading:10704997-Morphine, pubmed-meshheading:10704997-Nerve Fibers, pubmed-meshheading:10704997-Nerve Tissue Proteins, pubmed-meshheading:10704997-Neuralgia, pubmed-meshheading:10704997-Neuronal Plasticity, pubmed-meshheading:10704997-Neurons, Afferent, pubmed-meshheading:10704997-Neuropeptides, pubmed-meshheading:10704997-Nociceptors, pubmed-meshheading:10704997-Pain, pubmed-meshheading:10704997-Receptors, Metabotropic Glutamate, pubmed-meshheading:10704997-Receptors, N-Methyl-D-Aspartate, pubmed-meshheading:10704997-Receptors, Neurokinin-1, pubmed-meshheading:10704997-Reflex, pubmed-meshheading:10704997-Spinal Cord, pubmed-meshheading:10704997-Substance P, pubmed-meshheading:10704997-Synaptic Transmission, pubmed-meshheading:10704997-Viscera
pubmed:year
2000
pubmed:articleTitle
Wind-up of spinal cord neurones and pain sensation: much ado about something?
pubmed:affiliation
Departamento de Fisiología, Edificio de Medicina, Campus Universitario, Universidad de Alcalá, 28871 Alcalá de Henares, Madrid, Spain. ffjfhg@alcala.es
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't