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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2000-4-11
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pubmed:abstractText |
The expression of fas gene in glioma cells varies with growth stage. When insulin-elicited transient apoptosis of glioma cells was in progress, the expression of fas gene increased at both transcriptional and translational levels. In contrast, the expression of fas-L gene in glioma cells remained constant. Apoptosis occurred in the cells having high level of surface Fas protein. When the expression of Fas-L in U-373MG cells was suppressed by ribozyme, the insulin-elicited transient apoptosis vanished. Overexpression of Bcl-2 in U-373MG cells did not alter significantly the cell cycle progression and the expression of fas gene. However, these cells were resistant to insulin-trigged death. Therefore, insulin-elicited apoptosis involved Fas-related death signal, and which could be prevented by the protective effect of Bcl-2.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD95,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Surface,
http://linkedlifedata.com/resource/pubmed/chemical/Culture Media, Serum-Free,
http://linkedlifedata.com/resource/pubmed/chemical/FASLG protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Fas Ligand Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Hypoglycemic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-bcl-2,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Catalytic
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pubmed:status |
MEDLINE
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pubmed:issn |
1065-6995
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 1999 Academic Press.
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pubmed:issnType |
Print
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pubmed:volume |
23
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
533-40
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:10704237-Antigens, CD95,
pubmed-meshheading:10704237-Antigens, Surface,
pubmed-meshheading:10704237-Apoptosis,
pubmed-meshheading:10704237-Brain Neoplasms,
pubmed-meshheading:10704237-Cell Division,
pubmed-meshheading:10704237-Culture Media, Serum-Free,
pubmed-meshheading:10704237-Fas Ligand Protein,
pubmed-meshheading:10704237-Flow Cytometry,
pubmed-meshheading:10704237-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:10704237-Glioma,
pubmed-meshheading:10704237-Humans,
pubmed-meshheading:10704237-Hypoglycemic Agents,
pubmed-meshheading:10704237-Insulin,
pubmed-meshheading:10704237-Membrane Glycoproteins,
pubmed-meshheading:10704237-Proto-Oncogene Proteins c-bcl-2,
pubmed-meshheading:10704237-RNA, Catalytic,
pubmed-meshheading:10704237-Transcription, Genetic,
pubmed-meshheading:10704237-Transfection,
pubmed-meshheading:10704237-Tumor Cells, Cultured
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pubmed:year |
1999
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pubmed:articleTitle |
Transient apoptosis elicited by insulin in serum-starved glioma cells involves Fas/Fas-L and Bcl-2.
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pubmed:affiliation |
Department of Microbiology and Immunology, College of Medicine, National Cheng Kung University, Tainan, Taiwan, Republic of China. y1357@mail.ncku.edu.tw
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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