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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2000-3-23
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pubmed:abstractText |
Expression of activated leukocyte cell adhesion molecule (ALCAM)/CD166 correlates with the aggregation and metastatic capacity of human melanoma cell lines (Am J Pathol 1998, 152:805-813). Immunohistochemistry on a series of human melanocytic lesions reveals that ALCAM expression correlates with melanoma progression. Most nevi (34/38) and all thin melanomas studied (Clark levels I and II) did not express ALCAM. In contrast, immunoreactivity was detected in the invasive, vertical growth phase of 2 of the 13 Clark level III lesions tested. The fraction of positive lesions further increased in Clark level IV (13/19) and in Clark level V (4/4) lesions. ALCAM expression was exclusively detectable in the vertical growth phase of the primary tumor. In melanoma metastases, approximately half of the lesions tested (13/28) were ALCAM positive. According to the Breslow-thickness, ALCAM expression was observed in less than 10% of the lesions that were thinner than 1.5 mm and in over 70% of the lesions that were thicker than 1.5 mm. Our results strongly suggest that ALCAM plays an important role in melanocytic tumor progression and depict it as a new molecular marker for neoplastic progression of primary human melanoma.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/10702391-1698118,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10702391-2208139,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10702391-2253310,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10702391-3052592,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10702391-5477666,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10702391-5773814,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10702391-6500548,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10702391-6985715,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10702391-7535342,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10702391-7657508,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10702391-7760007,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10702391-7827878,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10702391-8162602,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10702391-8440920,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10702391-9108459,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10702391-9151136,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10702391-9357143,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10702391-9362419,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10702391-9481522,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10702391-9502422,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10702391-9676573,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10702391-9695818,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10702391-9740553,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10702391-9790298,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10702391-9811334,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10702391-9870879
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0002-9440
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
156
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
769-74
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:10702391-Activated-Leukocyte Cell Adhesion Molecule,
pubmed-meshheading:10702391-Disease Progression,
pubmed-meshheading:10702391-Humans,
pubmed-meshheading:10702391-Immunoenzyme Techniques,
pubmed-meshheading:10702391-Lentigo,
pubmed-meshheading:10702391-Melanoma,
pubmed-meshheading:10702391-Neoplasm Staging,
pubmed-meshheading:10702391-Nevus,
pubmed-meshheading:10702391-Skin,
pubmed-meshheading:10702391-Skin Neoplasms,
pubmed-meshheading:10702391-Tumor Markers, Biological
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pubmed:year |
2000
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pubmed:articleTitle |
Activated leukocyte cell adhesion molecule/CD166, a marker of tumor progression in primary malignant melanoma of the skin.
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pubmed:affiliation |
Department of Biochemistry, University of Nijmegen, Nijmegen, The Netherlands.
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pubmed:publicationType |
Journal Article
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