Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2000-3-17
pubmed:abstractText
The polymorphism of the angiotensin-converting enzyme gene is considered to be associated with increased risk for stroke, but there is a diversity in the results obtained. The genetic involvement of the renin-angiotensin system in stroke also remains unclear. To predict the genetic risk of lacunar infarction, we conducted an association study in an Ohasama population, which is the cohort in a rural region of northern Japan. A total of 134 subjects without major neurological, cardiovascular, or metabolic disorders were recruited. Using brain magnetic resonance imaging, the number of lacunae in each of four brain regions were calculated, and periventricular hyperintensity was classified into five grades. We used the following four candidate gene polymorphisms: angiotensin converting enzyme (ACE)/Insertion(I)-Deletion(D), angiotensinogen (AGT)/M235T, angiotensin II type 1 receptor (AT1)/ A1166C, type 2 receptor (AT2)/C3123A, to examine the association between polymorphisms and the severity of lacunar infarction. AGT/M235T was significantly associated with the number of lacunae in the brain stem, the basal ganglia (P < .05), and whole brain (P < .005) regions. The AT1 polymorphism was also significantly associated with the number of lacunae in the basal ganglia and whole brain regions (P < .05), and with periventricular hyperintensity grade (P < .005) in the younger population. However, ACE and AT2 polymorphisms failed to show an association with either the number of lacunae or the PVH grade. We concluded that AGT and AT1 polymorphisms are independent genetic risk factors for lacunar infarction.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0895-7061
pubmed:author
pubmed:issnType
Print
pubmed:volume
13
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
121-7
pubmed:dateRevised
2009-2-24
pubmed:meshHeading
pubmed-meshheading:10701810-Aged, pubmed-meshheading:10701810-Alleles, pubmed-meshheading:10701810-Angiotensin I, pubmed-meshheading:10701810-Angiotensin II, pubmed-meshheading:10701810-Brain, pubmed-meshheading:10701810-Brain Infarction, pubmed-meshheading:10701810-DNA, pubmed-meshheading:10701810-Female, pubmed-meshheading:10701810-Genotype, pubmed-meshheading:10701810-Humans, pubmed-meshheading:10701810-Incidence, pubmed-meshheading:10701810-Japan, pubmed-meshheading:10701810-Magnetic Resonance Imaging, pubmed-meshheading:10701810-Male, pubmed-meshheading:10701810-Middle Aged, pubmed-meshheading:10701810-Peptidyl-Dipeptidase A, pubmed-meshheading:10701810-Polymerase Chain Reaction, pubmed-meshheading:10701810-Polymorphism, Genetic, pubmed-meshheading:10701810-Renin-Angiotensin System, pubmed-meshheading:10701810-Risk Factors, pubmed-meshheading:10701810-Rural Population
pubmed:year
2000
pubmed:articleTitle
Gene polymorphism of the renin-angiotensin system associates with risk for lacunar infarction. The Ohasama study.
pubmed:affiliation
Department of Geriatric Medicine, Osaka University Medical School, Suita, Japan.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't