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PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2000-5-4
pubmed:abstractText
Soluble guanylate cyclase (sGC), the receptor for nitric oxide, is a heterodimer consisting of alpha and beta subunits. We investigated the mRNA species for the alpha(1) subunit in human brain, heart, artery and immortalized B-lymphocytes. Three mRNA species were identified in these tissues. The major mRNA species contained the full expression sequence of the alpha(1) subunit. Two other types of mRNA were detected in which 5' sequences were deleted by splicing (506-590 and 412-590). Each of these deletions included the predicted translation start site, indicating that translation of these two alternatively spliced RNA species does not result in the production of full-length alpha(1) subunits. The relative amounts of the two mRNA species with deletions of the translation start site differed significantly between cell lines of immortalized B-lymphocytes from different individuals. sGC enzymic activity was significantly decreased in cellular extracts from cell lines with high proportions of mRNA species containing the deletion 506-590 when compared with extracts from cell lines that contained mostly mRNA without this deletion.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/10698711-1352257, http://linkedlifedata.com/resource/pubmed/commentcorrection/10698711-1680753, http://linkedlifedata.com/resource/pubmed/commentcorrection/10698711-1683630, http://linkedlifedata.com/resource/pubmed/commentcorrection/10698711-1925582, http://linkedlifedata.com/resource/pubmed/commentcorrection/10698711-2355955, http://linkedlifedata.com/resource/pubmed/commentcorrection/10698711-2656699, http://linkedlifedata.com/resource/pubmed/commentcorrection/10698711-7477288, http://linkedlifedata.com/resource/pubmed/commentcorrection/10698711-7522969, http://linkedlifedata.com/resource/pubmed/commentcorrection/10698711-7545787, http://linkedlifedata.com/resource/pubmed/commentcorrection/10698711-7559610, http://linkedlifedata.com/resource/pubmed/commentcorrection/10698711-7673142, http://linkedlifedata.com/resource/pubmed/commentcorrection/10698711-7904602, http://linkedlifedata.com/resource/pubmed/commentcorrection/10698711-7923361, http://linkedlifedata.com/resource/pubmed/commentcorrection/10698711-8613461, http://linkedlifedata.com/resource/pubmed/commentcorrection/10698711-8613552, http://linkedlifedata.com/resource/pubmed/commentcorrection/10698711-8643658, http://linkedlifedata.com/resource/pubmed/commentcorrection/10698711-8779892, http://linkedlifedata.com/resource/pubmed/commentcorrection/10698711-9039111, http://linkedlifedata.com/resource/pubmed/commentcorrection/10698711-9357395, http://linkedlifedata.com/resource/pubmed/commentcorrection/10698711-9742212, http://linkedlifedata.com/resource/pubmed/commentcorrection/10698711-9884384
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0264-6021
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
346 Pt 3
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
811-6
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
2000
pubmed:articleTitle
Alternative splicing for the alpha1 subunit of soluble guanylate cyclase.
pubmed:affiliation
Department of Pathology, Saint Louis University School of Medicine, St Louis, MO 63104, USA. ritterdg@slu.edu
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't