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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
1977-2-26
|
| pubmed:abstractText |
To investigate the systemic, clinical and laboratory effects of iv polyriboinosinic-polyribocytidylic acid (poly I-poly C), 32 doses of poly I-poly C were administered to 22 patients. Doses between 1 and 10 mg/kg induced the formation of serum interferon (IF) and fever. Whereas a direct relationship was seen between the poly I-poly C dose and fever, serum IF levels were not significantly changed by increasing the dose of poly I-poly C over a log range from 1 to 10 mg/kg. Transient abnormalities were noted in liver function tests in 4 of 13 patients who received greater than 6.0 mg/kg. Other laboratory changes were confined to an increase in the absolute granulocyte count that paralleled fever development and abnormalities in coagulation parameters of 1 patient. In vitro lymphocyte DNA synthesis in response to mitogens was transiently impaired at times corresponding to serum IF appearance. These studies have established dose levels of poly I-poly C that can be safely administered to man with minimal toxicity and result in IF induction.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
|
| pubmed:issn |
0027-8874
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
57
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1211-6
|
| pubmed:dateRevised |
2007-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:1069859-Adult,
pubmed-meshheading:1069859-Aged,
pubmed-meshheading:1069859-Cells, Cultured,
pubmed-meshheading:1069859-Child, Preschool,
pubmed-meshheading:1069859-Dose-Response Relationship, Drug,
pubmed-meshheading:1069859-Female,
pubmed-meshheading:1069859-Fever,
pubmed-meshheading:1069859-Humans,
pubmed-meshheading:1069859-Injections, Intravenous,
pubmed-meshheading:1069859-Interferons,
pubmed-meshheading:1069859-Leukemia,
pubmed-meshheading:1069859-Leukemia, Myeloid, Acute,
pubmed-meshheading:1069859-Leukocyte Count,
pubmed-meshheading:1069859-Liver,
pubmed-meshheading:1069859-Lymphocyte Activation,
pubmed-meshheading:1069859-Male,
pubmed-meshheading:1069859-Middle Aged,
pubmed-meshheading:1069859-Neoplasms,
pubmed-meshheading:1069859-Neutrophils,
pubmed-meshheading:1069859-Poly I-C
|
| pubmed:year |
1976
|
| pubmed:articleTitle |
Ssytemic effects of intravenous polyriboinosinic-polyribocytidylic acid in man.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|