rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
2
|
pubmed:dateCreated |
2000-3-31
|
pubmed:abstractText |
105Rh has favorable physical characteristics as a radiotherapeutic nuclide. Carrier-free 105Rh can be produced by the neutron activation of 104Ru followed by beta decay of 105Ru. It was clarified that carrier-free 105Rh can be produced in quantities and the purity necessary for chemical and clinical investigations of its use as a nuclide for radiotherapy. 105Rh-EDTMP was simply obtained from 105Rh3+ and EDTMP by heating for 30 min in boiling water, giving a radiochemical yield of > 99%. Dissociation of radioactivity assessed by paperchromatography was negligible for up to 5 days after its preparation. In animals, 105Rh-EDTMP showed rapid blood clearance and selective uptake in the bone. Hence, 105Rh-EDTMP is thought to be a promising therapeutic agent for the treatment of pain due to bone metastases.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Feb
|
pubmed:issn |
0969-8043
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
52
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
211-5
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:10697730-Animals,
pubmed-meshheading:10697730-Bone and Bones,
pubmed-meshheading:10697730-Male,
pubmed-meshheading:10697730-Mice,
pubmed-meshheading:10697730-Mice, Inbred Strains,
pubmed-meshheading:10697730-Neutrons,
pubmed-meshheading:10697730-Organometallic Compounds,
pubmed-meshheading:10697730-Phosphonic Acids,
pubmed-meshheading:10697730-Radiopharmaceuticals,
pubmed-meshheading:10697730-Rhodium,
pubmed-meshheading:10697730-Technetium Tc 99m Medronate,
pubmed-meshheading:10697730-Time Factors,
pubmed-meshheading:10697730-Tissue Distribution
|
pubmed:year |
2000
|
pubmed:articleTitle |
Production of 105Rh-EDTMP and its bone accumulation.
|
pubmed:affiliation |
School of Health Sciences, Faculty of Medicine, Kanazawa University, Japan. ando@kenroku.kanazawa-u.ac.jp
|
pubmed:publicationType |
Journal Article,
Comparative Study
|