Source:http://linkedlifedata.com/resource/pubmed/id/10695724
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1-2
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| pubmed:dateCreated |
2000-3-9
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| pubmed:abstractText |
Certain functional interactions between the nervous, endocrine, and immune systems are mediated by cytokines. The pro-inflammatory cytokines, interleukin-1 (IL-1) and tumor necrosis factor (TNF) were among the first to be recognized in this regard. A modulator of these cytokines, IL-10, has been shown to have a wide range of activities in the immune system; in this review, we describe its production and actions in the hypothalamic-pituitary-adrenal (HPA) axis. IL-10 is produced in pituitary, hypothalamic, and neural tissues in addition to lymphocytes. IL-10 enhances corticotropin releasing factor (CRF) and corticotropin (ACTH) production in hypothalamic and pituitary tissues, respectively. Further downstream in the HPA axis endogenous IL-10 has the potential to contribute to regulation of glucocorticosteroid production both tonically and following stressors. Our studies and those of others reviewed here indicate that IL-10 may be an important endogenous regulator in HPA axis activity and in CNS pathologies such as multiple sclerosis. Thus, in addition to its more widely recognized role in immunity, IL-10's neuroendocrine activities described here point to its role as an important regulator in communication between the immune and neuroendocrine systems.
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| pubmed:grant | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
|
| pubmed:issn |
0165-5728
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
100
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
140-8
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| pubmed:dateRevised |
2008-11-21
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| pubmed:meshHeading |
pubmed-meshheading:10695724-Adrenocorticotropic Hormone,
pubmed-meshheading:10695724-Animals,
pubmed-meshheading:10695724-Base Sequence,
pubmed-meshheading:10695724-Brain,
pubmed-meshheading:10695724-Cells, Cultured,
pubmed-meshheading:10695724-Dose-Response Relationship, Drug,
pubmed-meshheading:10695724-Humans,
pubmed-meshheading:10695724-Hypothalamo-Hypophyseal System,
pubmed-meshheading:10695724-Interferon-gamma,
pubmed-meshheading:10695724-Interleukin-10,
pubmed-meshheading:10695724-Mice,
pubmed-meshheading:10695724-Models, Biological,
pubmed-meshheading:10695724-Molecular Sequence Data,
pubmed-meshheading:10695724-NF-kappa B,
pubmed-meshheading:10695724-Pituitary-Adrenal System,
pubmed-meshheading:10695724-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:10695724-Spleen,
pubmed-meshheading:10695724-Temperature,
pubmed-meshheading:10695724-Tissue Distribution
|
| pubmed:year |
1999
|
| pubmed:articleTitle |
IL-10 as a mediator in the HPA axis and brain.
|
| pubmed:affiliation |
Department of Psychiatry and Behavioral Sciences, The University of Texas Medical Branch, Galveston 77555-0431, USA. esmith@utmb.edu
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| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Review
|