Source:http://linkedlifedata.com/resource/pubmed/id/10683765
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
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| pubmed:dateCreated |
2000-3-23
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| pubmed:abstractText |
This study deals with individual and species variations in the converting activity of methotrexate (MTX) to 7-hydroxymethotrexate in animals and humans. When MTX 7-hydroxylase was assayed in six human liver cytosols, a 48-fold range of intersubject variation of the activity was observed. The variations were correlated to the concentrations of aldehyde oxidase activity in human subjects assayed with benzaldehyde as a substrate. Species differences of liver MTX 7-hydroxylase activity were also observed. The activity was highest in rabbits, followed by rats, hamsters, and monkeys but was undetectable in dogs. Strain differences of MTX 7-hydroxylase activity based on aldehyde oxidase activity were also observed in rats and mice. The results suggest that aldehyde oxidase functions as MTX 7-hydroxylase in livers of animals and humans, and the observed differences of MTX 7-hydroxylase activity are due to variations in the amount of aldehyde oxidase present.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
|
| pubmed:issn |
1521-6543
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
48
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
607-11
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:10683765-Adult,
pubmed-meshheading:10683765-Animals,
pubmed-meshheading:10683765-Child, Preschool,
pubmed-meshheading:10683765-Cricetinae,
pubmed-meshheading:10683765-Dogs,
pubmed-meshheading:10683765-Female,
pubmed-meshheading:10683765-Guinea Pigs,
pubmed-meshheading:10683765-Humans,
pubmed-meshheading:10683765-Liver,
pubmed-meshheading:10683765-Macaca mulatta,
pubmed-meshheading:10683765-Male,
pubmed-meshheading:10683765-Mesocricetus,
pubmed-meshheading:10683765-Methotrexate,
pubmed-meshheading:10683765-Mice,
pubmed-meshheading:10683765-Mice, Inbred C3H,
pubmed-meshheading:10683765-Mice, Inbred C57BL,
pubmed-meshheading:10683765-Mice, Inbred DBA,
pubmed-meshheading:10683765-Middle Aged,
pubmed-meshheading:10683765-Mixed Function Oxygenases,
pubmed-meshheading:10683765-Rabbits,
pubmed-meshheading:10683765-Rats,
pubmed-meshheading:10683765-Rats, Sprague-Dawley
|
| pubmed:year |
1999
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| pubmed:articleTitle |
Variation of hepatic methotrexate 7-hydroxylase activity in animals and humans.
|
| pubmed:affiliation |
Institute of Pharmaceutical Science, Hiroshima University School of Medicine, Japan. kitamura@pharm.hiroshima-u.ac.jp
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| pubmed:publicationType |
Journal Article,
Comparative Study
|