Linked Life Data

10679083

Source:http://linkedlifedata.com/resource/pubmed/id/10679083

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2000-3-23
pubmed:abstractText
Mucosal addressin cell adhesion molecule-1 (MAdCAM-1) is essential for lymphocyte trafficking to gut-associated lymphoid tissues and is implicated in inflammatory disorders in the gut and pancreatic islets. In this study, we examined the functional role of MAdCAM-1 during rat ontogeny using newly generated specific mAb. As previously observed in mice and humans, MAdCAM-1 was preferentially expressed in high endothelial venules (HEV) in gut-associated lymphoid tissues and venules of lamina propria in adult rats. Lymphocyte rolling and adhesion on HEV in Peyer's patches (PP) were completely abrogated with neutralizing anti-MAdCAM-1 mAb, in agreement with the notion that MAdCAM-1 is the principal HEV ligand for lymphocyte rolling and adhesion in adult PP. In the developing gastrointestinal tract, MAdCAM-1 was widely expressed in the venules of the lamina propria of fetal rats. In addition, MAdCAM-1 was also expressed in follicular dendritic cells in the neonatal PP. Interestingly, MAdCAM-1 expression was found also in nonmucosal tissues during ontogeny. MAdCAM-1 was transiently expressed in blood vascular endothelial cells in the fetal skin and neonatal thymus. Notably, MAdCAM-1-positive blood vessels were localized mainly in the cortico-medullary junction in the neonatal thymus and about 10-20% of thymocytes, most of which were either CD4, CD8 double positive or single positive specifically reacted with soluble MAdCAM-1 via integrin alpha4beta7. After birth, MAdCAM-1 expression in thymus blood vessels disappeared and concomitantly, the soluble MAdCAM-1-reactive thymocytes were rapidly down-regulated. Our results suggest that MAdCAM-1 functions as a vascular addressin in not only mucosal, but also nonmucosal lymphoid tissues during ontogeny.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0022-1767
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
164
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2463-71
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:10679083-Aging, pubmed-meshheading:10679083-Animals, pubmed-meshheading:10679083-Animals, Newborn, pubmed-meshheading:10679083-Antibodies, Monoclonal, pubmed-meshheading:10679083-Antibody Specificity, pubmed-meshheading:10679083-Cell Adhesion, pubmed-meshheading:10679083-Cell Adhesion Molecules, pubmed-meshheading:10679083-Cell Movement, pubmed-meshheading:10679083-Embryonic and Fetal Development, pubmed-meshheading:10679083-Endothelium, Lymphatic, pubmed-meshheading:10679083-Female, pubmed-meshheading:10679083-Humans, pubmed-meshheading:10679083-Immunoglobulins, pubmed-meshheading:10679083-Intestinal Mucosa, pubmed-meshheading:10679083-Male, pubmed-meshheading:10679083-Mice, pubmed-meshheading:10679083-Mice, Inbred BALB C, pubmed-meshheading:10679083-Mucoproteins, pubmed-meshheading:10679083-Peyer's Patches, pubmed-meshheading:10679083-Rats, pubmed-meshheading:10679083-Rats, Wistar, pubmed-meshheading:10679083-Skin, pubmed-meshheading:10679083-Thymus Gland
pubmed:year
2000
pubmed:articleTitle
Stage-specific expression of mucosal addressin cell adhesion molecule-1 during embryogenesis in rats.
pubmed:affiliation
Department of Bioregulation, Biomedical Research Center, Osaka University Graduate School of Medicine, Osaka, Japan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't