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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2000-3-14
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pubmed:abstractText |
Multimerization of the MHC class II molecule by superantigens results in activation of cellular signal transduction pathways in macrophage and B cells. Here we show that superantigen staphylococcal enterotoxin B (SEB) induces IL-12/p40 secretion in macrophages. SEB-induced expression of the IL-12/p40 gene involves activation and nuclear translocation of nuclear factor kappaB (NF-kappaB). The NF-kappaB heterodimer bound to the NF-kappaB consensus sequence of the IL-12/p40 gene promoter is p50/C-Rel. Inhibition of PKC and PKA activation results in suppression of activation and translocation of NF-kappaB. We conclude that signals for IL-12/p40 gene transcription from MHC class II molecules follow activation of PKC and PKA, which in turn leads to the activation and translocation of NF-kappaB to the nucleus. Our study suggests that superantigens are capable of influencing the nature of the immune response by regulating cytokine production. Induction of IL-12 production by superantigens may therefore play a role in the regulation of Th 1-mediated immune response and autoimmune disease.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0008-8749
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2000 Academic Press.
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pubmed:issnType |
Print
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pubmed:day |
10
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pubmed:volume |
199
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
50-7
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:10675275-Animals,
pubmed-meshheading:10675275-Binding, Competitive,
pubmed-meshheading:10675275-Cell Nucleus,
pubmed-meshheading:10675275-Cells, Cultured,
pubmed-meshheading:10675275-Cyclic AMP-Dependent Protein Kinases,
pubmed-meshheading:10675275-DNA,
pubmed-meshheading:10675275-Genes, MHC Class II,
pubmed-meshheading:10675275-Histocompatibility Antigens Class II,
pubmed-meshheading:10675275-Interleukin-12,
pubmed-meshheading:10675275-Ligands,
pubmed-meshheading:10675275-Lipopolysaccharides,
pubmed-meshheading:10675275-Macrophages,
pubmed-meshheading:10675275-Mice,
pubmed-meshheading:10675275-Mice, Inbred Strains,
pubmed-meshheading:10675275-Mice, Knockout,
pubmed-meshheading:10675275-NF-kappa B,
pubmed-meshheading:10675275-Promoter Regions, Genetic,
pubmed-meshheading:10675275-Protein Kinase C,
pubmed-meshheading:10675275-Receptor Aggregation,
pubmed-meshheading:10675275-Signal Transduction,
pubmed-meshheading:10675275-Superantigens,
pubmed-meshheading:10675275-Up-Regulation
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pubmed:year |
2000
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pubmed:articleTitle |
Induction of interleukin-12/p40 by superantigens in macrophages is mediated by activation of nuclear factor-kappaB.
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pubmed:affiliation |
Department of Neurology, Multiple Sclerosis Research Center, Vanderbilt University Medical Center, Nashville, Tennessee 37212, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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