Linked Life Data

10672339

Source:http://linkedlifedata.com/resource/pubmed/id/10672339

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2000-4-11
pubmed:abstractText
Fv-4 is a truncated ecotropic retrovirus gene that codes for an envelope protein under control of a cellular promoter. It confers resistance to ecotropic murine leukemia viruses. Transgenic mice were derived using the native Fv-4 gene as the construct for microinjection. Two founder mice were derived. In both founder lines, there was no detectable expression of the transgene or resistance to Friend murine leukemia virus (FrMLV) in hemizygotes. In one line, the resistance was observed in homozygotes with Fv-4 RNA formation in the thymus but not in the spleen or in other tissues. In the other founder line, a homozygous male was identified. Double integrants, derived from breeding this homozygous male to homozygous females from the other founder line, were also resistant. These results indicate that the native gene confers the resistance in homozygous transgenic mice or double integrants derived from different founders but not hemizygotes.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0001-723X
pubmed:author
pubmed:issnType
Print
pubmed:volume
43
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
19-23
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1999
pubmed:articleTitle
Resistance to Friend leukemia virus in transgenic mice expressing the native Fv-4 gene.
pubmed:affiliation
Department of Animal, Dairy and Veterinary Sciences, Utah State University, Logan 84322-5700, USA.
pubmed:publicationType
Journal Article