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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2000-3-1
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pubmed:abstractText |
CD4+ T cells play an essential role in allograft rejection. The monoclonal anti-rat CD4 antibody, RIB 5/2, has been shown to modulate the CD4 glycoprotein without eliminating the recipient T cells. We have successfully induced tolerance to rat heart allografts by recipient pretreatment with a single dose of RIB 5/2 plus intravenous administration of donor splenocytes. In this study, we explored whether this potent regimen could induce tolerance to the more resistant kidney and skin allografts. Furthermore, we examined the kinetics and requirements for tolerance to be met by a single dose of RIB 5/2 plus i.v. alloantigen.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0041-1337
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
27
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pubmed:volume |
69
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
285-93
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:10670640-Adoptive Transfer,
pubmed-meshheading:10670640-Animals,
pubmed-meshheading:10670640-Antibodies, Monoclonal,
pubmed-meshheading:10670640-Antigens, CD4,
pubmed-meshheading:10670640-Graft Survival,
pubmed-meshheading:10670640-Heart Transplantation,
pubmed-meshheading:10670640-Immune Tolerance,
pubmed-meshheading:10670640-Injections, Intravenous,
pubmed-meshheading:10670640-Interleukin-2,
pubmed-meshheading:10670640-Isoantigens,
pubmed-meshheading:10670640-Kidney Transplantation,
pubmed-meshheading:10670640-Kinetics,
pubmed-meshheading:10670640-Male,
pubmed-meshheading:10670640-Rats,
pubmed-meshheading:10670640-Rats, Inbred BN,
pubmed-meshheading:10670640-Rats, Inbred BUF,
pubmed-meshheading:10670640-Rats, Inbred Lew,
pubmed-meshheading:10670640-Recombinant Proteins,
pubmed-meshheading:10670640-Skin Transplantation,
pubmed-meshheading:10670640-Spleen,
pubmed-meshheading:10670640-Tissue Donors
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pubmed:year |
2000
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pubmed:articleTitle |
The kinetics of tolerance induction by nondepleting anti-CD4 monoclonal antibody (RIB 5/2) plus intravenous donor alloantigen administration.
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pubmed:affiliation |
Department of Surgery, Washington University School of Medicine, St. Louis, MO 63110, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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