| pubmed-article:10669323 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10669323 | lifeskim:mentions | umls-concept:C0220847 | lld:lifeskim |
| pubmed-article:10669323 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:10669323 | lifeskim:mentions | umls-concept:C0087111 | lld:lifeskim |
| pubmed-article:10669323 | lifeskim:mentions | umls-concept:C0332307 | lld:lifeskim |
| pubmed-article:10669323 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:10669323 | lifeskim:mentions | umls-concept:C0026882 | lld:lifeskim |
| pubmed-article:10669323 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:10669323 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:10669323 | lifeskim:mentions | umls-concept:C0332281 | lld:lifeskim |
| pubmed-article:10669323 | lifeskim:mentions | umls-concept:C1514562 | lld:lifeskim |
| pubmed-article:10669323 | lifeskim:mentions | umls-concept:C1883221 | lld:lifeskim |
| pubmed-article:10669323 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:10669323 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:10669323 | lifeskim:mentions | umls-concept:C1883204 | lld:lifeskim |
| pubmed-article:10669323 | lifeskim:mentions | umls-concept:C1880389 | lld:lifeskim |
| pubmed-article:10669323 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:10669323 | pubmed:dateCreated | 2000-4-13 | lld:pubmed |
| pubmed-article:10669323 | pubmed:abstractText | An interaction of the hepatitis C virus (HCV) NS5A protein with the interferon (IFN)-alpha-inducible double-stranded RNA-activated protein kinase (PKR) was demonstrated in vitro. The clinical correlation between amino acid mutations within the HCV NS5A region and response to antiviral treatment is controversial. Thirty-two patients chronically infected with HCV-1a, who were treated with IFN-alpha with or without ribavirin, were studied. The carboxy-terminal half of HCV NS5A was sequenced and was investigated by phylogenetic and conformational analyses. Eight patients achieved a sustained virologic response. An end-of-treatment response but relapse thereafter was observed among 8 patients, whereas 16 patients were nonresponders. The median number of mutations within the PKR-binding domain but not within the previously described IFN sensitivity-determining region was significantly higher for patients with sustained (3 mutations [range, 1-5]) or end-of-treatment (4 mutations [range, 1-5]) virologic response than for nonresponders (2 mutations [range, 0-3]) (P=.0087). Phylogenetic and conformational analyses of NS5A sequences allowed no differentiation between sensitive and resistant strains. | lld:pubmed |
| pubmed-article:10669323 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10669323 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10669323 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:10669323 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10669323 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10669323 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10669323 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10669323 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10669323 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10669323 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10669323 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10669323 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10669323 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10669323 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:10669323 | pubmed:issn | 0022-1899 | lld:pubmed |
| pubmed-article:10669323 | pubmed:author | pubmed-author:BergTT | lld:pubmed |
| pubmed-article:10669323 | pubmed:author | pubmed-author:LeeJ HJH | lld:pubmed |
| pubmed-article:10669323 | pubmed:author | pubmed-author:SarrazinCC | lld:pubmed |
| pubmed-article:10669323 | pubmed:author | pubmed-author:RoweW AWA | lld:pubmed |
| pubmed-article:10669323 | pubmed:author | pubmed-author:ZeuzemSS | lld:pubmed |
| pubmed-article:10669323 | pubmed:author | pubmed-author:SANTANAZZ | lld:pubmed |
| pubmed-article:10669323 | pubmed:author | pubmed-author:KronenbergerB... | lld:pubmed |
| pubmed-article:10669323 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10669323 | pubmed:volume | 181 | lld:pubmed |
| pubmed-article:10669323 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10669323 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10669323 | pubmed:pagination | 432-41 | lld:pubmed |
| pubmed-article:10669323 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
| pubmed-article:10669323 | pubmed:meshHeading | pubmed-meshheading:10669323... | lld:pubmed |
| pubmed-article:10669323 | pubmed:meshHeading | pubmed-meshheading:10669323... | lld:pubmed |
| pubmed-article:10669323 | pubmed:meshHeading | pubmed-meshheading:10669323... | lld:pubmed |
| pubmed-article:10669323 | pubmed:meshHeading | pubmed-meshheading:10669323... | lld:pubmed |
| pubmed-article:10669323 | pubmed:meshHeading | pubmed-meshheading:10669323... | lld:pubmed |
| pubmed-article:10669323 | pubmed:meshHeading | pubmed-meshheading:10669323... | lld:pubmed |
| pubmed-article:10669323 | pubmed:meshHeading | pubmed-meshheading:10669323... | lld:pubmed |
| pubmed-article:10669323 | pubmed:meshHeading | pubmed-meshheading:10669323... | lld:pubmed |
| pubmed-article:10669323 | pubmed:meshHeading | pubmed-meshheading:10669323... | lld:pubmed |
| pubmed-article:10669323 | pubmed:meshHeading | pubmed-meshheading:10669323... | lld:pubmed |
| pubmed-article:10669323 | pubmed:meshHeading | pubmed-meshheading:10669323... | lld:pubmed |
| pubmed-article:10669323 | pubmed:meshHeading | pubmed-meshheading:10669323... | lld:pubmed |
| pubmed-article:10669323 | pubmed:meshHeading | pubmed-meshheading:10669323... | lld:pubmed |
| pubmed-article:10669323 | pubmed:meshHeading | pubmed-meshheading:10669323... | lld:pubmed |
| pubmed-article:10669323 | pubmed:meshHeading | pubmed-meshheading:10669323... | lld:pubmed |
| pubmed-article:10669323 | pubmed:meshHeading | pubmed-meshheading:10669323... | lld:pubmed |
| pubmed-article:10669323 | pubmed:meshHeading | pubmed-meshheading:10669323... | lld:pubmed |
| pubmed-article:10669323 | pubmed:meshHeading | pubmed-meshheading:10669323... | lld:pubmed |
| pubmed-article:10669323 | pubmed:meshHeading | pubmed-meshheading:10669323... | lld:pubmed |
| pubmed-article:10669323 | pubmed:meshHeading | pubmed-meshheading:10669323... | lld:pubmed |
| pubmed-article:10669323 | pubmed:meshHeading | pubmed-meshheading:10669323... | lld:pubmed |
| pubmed-article:10669323 | pubmed:meshHeading | pubmed-meshheading:10669323... | lld:pubmed |
| pubmed-article:10669323 | pubmed:meshHeading | pubmed-meshheading:10669323... | lld:pubmed |
| pubmed-article:10669323 | pubmed:meshHeading | pubmed-meshheading:10669323... | lld:pubmed |
| pubmed-article:10669323 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10669323 | pubmed:articleTitle | Mutations in the protein kinase-binding domain of the NS5A protein in patients infected with hepatitis C virus type 1a are associated with treatment response. | lld:pubmed |
| pubmed-article:10669323 | pubmed:affiliation | Medizinische Klinik II, J. W. Goethe-University, Frankfurt am Main, Germany. | lld:pubmed |
| pubmed-article:10669323 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10669323 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10669323 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10669323 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10669323 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10669323 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10669323 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10669323 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10669323 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10669323 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10669323 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10669323 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10669323 | lld:pubmed |
