Source:http://linkedlifedata.com/resource/pubmed/id/10658012
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
2000-3-3
|
| pubmed:abstractText |
We sought to investigate further the roles of sweating, ACh spillover, and nitric oxide (NO) in the neurally mediated cutaneous vasodilation during body heating in humans. Six subjects were heated with a water-perfused suit while cutaneous blood flow was measured with a laser-Doppler flowmeter. After a rise in core temperature (1. 0 +/- 0.1 degrees C) and the establishment of cutaneous vasodilation, atropine and subsequently the NO synthase inhibitor N(G)-nitro-L-arginine methyl ester (L-NAME) were given to the forearm via a brachial artery catheter. After atropine infusion, cutaneous vascular conductance (CVC) remained constant in five of six subjects, whereas L-NAME administration blunted the rise in CVC in three of six subjects. A subsequent set of studies using intradermal microdialysis probes to selectively deliver drugs into forearm skin confirmed that atropine did not affect CVC. However, perfusion of L-NAME resulted in a significant decrease in CVC (37 +/- 4%, P < 0.05). The results indicate that neither sweating nor NO release via muscarinic receptor activation is essential to sustain cutaneous dilation during heating in humans.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
|
| pubmed:issn |
8750-7587
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
88
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
467-72
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| pubmed:dateRevised |
2008-11-21
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| pubmed:meshHeading |
pubmed-meshheading:10658012-Adult,
pubmed-meshheading:10658012-Atropine,
pubmed-meshheading:10658012-Body Temperature,
pubmed-meshheading:10658012-Brachial Artery,
pubmed-meshheading:10658012-Enzyme Inhibitors,
pubmed-meshheading:10658012-Female,
pubmed-meshheading:10658012-Humans,
pubmed-meshheading:10658012-Infant, Newborn,
pubmed-meshheading:10658012-Infusion Pumps,
pubmed-meshheading:10658012-Male,
pubmed-meshheading:10658012-Microdialysis,
pubmed-meshheading:10658012-NG-Nitroarginine Methyl Ester,
pubmed-meshheading:10658012-Parasympatholytics,
pubmed-meshheading:10658012-Regional Blood Flow,
pubmed-meshheading:10658012-Skin,
pubmed-meshheading:10658012-Skin Physiological Phenomena,
pubmed-meshheading:10658012-Sweating,
pubmed-meshheading:10658012-Time Factors,
pubmed-meshheading:10658012-Vascular Resistance
|
| pubmed:year |
2000
|
| pubmed:articleTitle |
Effects of atropine and L-NAME on cutaneous blood flow during body heating in humans.
|
| pubmed:affiliation |
Department of Physiology and Biophysics, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA.
|
| pubmed:publicationType |
Journal Article,
Clinical Trial,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|