Linked Life Data

10657653

Source:http://linkedlifedata.com/resource/pubmed/id/10657653

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2000-3-9
pubmed:abstractText
Human alveolar macrophages (AMphi) undergo apoptosis following infection with Mycobacterium tuberculosis in vitro. Apoptosis of cells infected with intracellular pathogens may benefit the host by eliminating a supportive environment for bacterial growth. The present study compared AMphi apoptosis following infection by M. tuberculosis complex strains of differing virulence and by Mycobacterium kansasii. Avirulent or attenuated bacilli (M. tuberculosis H37Ra, Mycobacterium bovis bacillus Calmette-Guérin, and M. kansasii) induced significantly more AMphi apoptosis than virulent strains (M. tuberculosis H37Rv, Erdman, M. tuberculosis clinical isolate BMC 96.1, and M. bovis wild type). Increased apoptosis was not due to greater intracellular bacterial replication because virulent strains grew more rapidly in AMphi than attenuated strains despite causing less apoptosis. These findings suggest the existence of mycobacterial virulence determinants that modulate the apoptotic response of AMphi to intracellular infection and support the hypothesis that macrophage apoptosis contributes to innate host defense in tuberculosis.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0022-1767
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
164
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2016-20
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed-meshheading:10657653-Antigens, CD, pubmed-meshheading:10657653-Apoptosis, pubmed-meshheading:10657653-Cell-Free System, pubmed-meshheading:10657653-Cells, Cultured, pubmed-meshheading:10657653-Cytotoxicity, Immunologic, pubmed-meshheading:10657653-Humans, pubmed-meshheading:10657653-Interleukin-10, pubmed-meshheading:10657653-Intracellular Fluid, pubmed-meshheading:10657653-Macrophages, Alveolar, pubmed-meshheading:10657653-Mycobacterium kansasii, pubmed-meshheading:10657653-Mycobacterium tuberculosis, pubmed-meshheading:10657653-Receptors, Tumor Necrosis Factor, pubmed-meshheading:10657653-Receptors, Tumor Necrosis Factor, Type II, pubmed-meshheading:10657653-Solubility, pubmed-meshheading:10657653-Tumor Necrosis Factor-alpha, pubmed-meshheading:10657653-Vaccines, Attenuated, pubmed-meshheading:10657653-Virulence
pubmed:year
2000
pubmed:articleTitle
Virulent Mycobacterium tuberculosis strains evade apoptosis of infected alveolar macrophages.
pubmed:affiliation
Pulmonary Center, Boston University School of Medicine, Boston MA 02118, USA. jkeane@lung.bumc.bu.edu
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't