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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2000-2-17
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pubmed:abstractText |
Trypsin and mast cell tryptase cleave proteinase-activated receptor 2 and, by unknown mechanisms, induce widespread inflammation. We found that a large proportion of primary spinal afferent neurons, which express proteinase-activated receptor 2, also contain the proinflammatory neuropeptides calcitonin gene-related peptide and substance P. Trypsin and tryptase directly signal to neurons to stimulate release of these neuropeptides, which mediate inflammatory edema induced by agonists of proteinase-activated receptor 2. This new mechanism of protease-induced neurogenic inflammation may contribute to the proinflammatory effects of mast cells in human disease. Thus, tryptase inhibitors and antagonists of proteinase-activated receptor 2 may be useful anti-inflammatory agents.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Calcitonin Gene-Related Peptide,
http://linkedlifedata.com/resource/pubmed/chemical/Chymases,
http://linkedlifedata.com/resource/pubmed/chemical/DNA Probes,
http://linkedlifedata.com/resource/pubmed/chemical/Mcpt6 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, PAR-2,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Thrombin,
http://linkedlifedata.com/resource/pubmed/chemical/Serine Endopeptidases,
http://linkedlifedata.com/resource/pubmed/chemical/Substance P,
http://linkedlifedata.com/resource/pubmed/chemical/TPSB1 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Trypsin,
http://linkedlifedata.com/resource/pubmed/chemical/Tryptases,
http://linkedlifedata.com/resource/pubmed/chemical/chymase 2
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1078-8956
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pubmed:author |
pubmed-author:AmadesiSS,
pubmed-author:BunnettN WNW,
pubmed-author:CaugheyG HGH,
pubmed-author:EnnesH SHS,
pubmed-author:GeppettiPP,
pubmed-author:HollenbergM DMD,
pubmed-author:MayesE BEB,
pubmed-author:MitchellS ESE,
pubmed-author:SteinhoffMM,
pubmed-author:TognettiGG,
pubmed-author:TrevisaniMM,
pubmed-author:VergnolleNN,
pubmed-author:WallaceJ LJL,
pubmed-author:WilliamsL MLM,
pubmed-author:YoungS HSH
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pubmed:issnType |
Print
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pubmed:volume |
6
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
151-8
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:10655102-Animals,
pubmed-meshheading:10655102-Base Sequence,
pubmed-meshheading:10655102-Calcitonin Gene-Related Peptide,
pubmed-meshheading:10655102-Chymases,
pubmed-meshheading:10655102-DNA Probes,
pubmed-meshheading:10655102-Ganglia, Spinal,
pubmed-meshheading:10655102-Humans,
pubmed-meshheading:10655102-In Situ Hybridization,
pubmed-meshheading:10655102-Inflammation,
pubmed-meshheading:10655102-Male,
pubmed-meshheading:10655102-Neurons,
pubmed-meshheading:10655102-Rats,
pubmed-meshheading:10655102-Rats, Sprague-Dawley,
pubmed-meshheading:10655102-Rats, Wistar,
pubmed-meshheading:10655102-Receptor, PAR-2,
pubmed-meshheading:10655102-Receptors, Thrombin,
pubmed-meshheading:10655102-Serine Endopeptidases,
pubmed-meshheading:10655102-Signal Transduction,
pubmed-meshheading:10655102-Substance P,
pubmed-meshheading:10655102-Trypsin,
pubmed-meshheading:10655102-Tryptases
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pubmed:year |
2000
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pubmed:articleTitle |
Agonists of proteinase-activated receptor 2 induce inflammation by a neurogenic mechanism.
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pubmed:affiliation |
Department of Surgery and Physiology, University of California, San Francisco, CA 94143, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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