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rdf:type |
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lifeskim:mentions |
umls-concept:C0003069,
umls-concept:C0008109,
umls-concept:C0019733,
umls-concept:C0030956,
umls-concept:C0205171,
umls-concept:C0205314,
umls-concept:C0206745,
umls-concept:C0337112,
umls-concept:C0679622,
umls-concept:C1417683,
umls-concept:C1524075,
umls-concept:C1880022,
umls-concept:C1979927
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pubmed:issue |
3
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pubmed:dateCreated |
2000-3-3
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pubmed:abstractText |
The MUC1 protein was found to be up-regulated in a spectrum of malignant tumors. T-cell responses to the MUC1 extracellular tandem repeat array (TRA) were observed in murine models as well as in breast-carcinoma patients. In the present study, we evaluated the anti-tumor potential of HLA-A2.1-motif-selected peptides from non-TRA domains of the molecule. Peptide immunogenicity was examined in the Db-/- x beta2 microglobulin (beta2m) null mice transgenic for a modified HLA-A2.1/Db-beta2 microglobulin single chain (HHD mice). Our results show the existence of 3 novel HLA-A2.1-restricted MUC1-derived cytotoxic T-lymphocyte (CTL) epitopes. These peptides are processed and presented by the HHD-transfected breast-tumor cell line MDA-MB-157. Moreover, CTL induced by these 3 peptides show higher lysis of target cells pulsed with breast-carcinoma-derived peptides than of targets pulsed with normal breast-tissue-derived peptides. These data suggest an important role for non-TRA MUC1-derived peptides as inducers of a MHC-restricted CTL reaction to a breast-carcinoma cell line and patient-derived tumor extracts.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cancer Vaccines,
http://linkedlifedata.com/resource/pubmed/chemical/Epitopes, T-Lymphocyte,
http://linkedlifedata.com/resource/pubmed/chemical/H-2 Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-A2 Antigen,
http://linkedlifedata.com/resource/pubmed/chemical/MUC1 tandem repeat peptide,
http://linkedlifedata.com/resource/pubmed/chemical/Mucin-1,
http://linkedlifedata.com/resource/pubmed/chemical/Peptide Fragments,
http://linkedlifedata.com/resource/pubmed/chemical/Peptides,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Fusion Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/beta 2-Microglobulin,
http://linkedlifedata.com/resource/pubmed/chemical/histocompatibility antigen H-2D(b)
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0020-7136
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pubmed:author |
pubmed-author:CarmonLL,
pubmed-author:EisenbachLL,
pubmed-author:El-ShamiK MKM,
pubmed-author:FeldmanMM,
pubmed-author:FridkinMM,
pubmed-author:KorenRR,
pubmed-author:LemonnierF AFA,
pubmed-author:PascoloSS,
pubmed-author:PazAA,
pubmed-author:TiroshBB,
pubmed-author:TzehovalEE
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
85
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
391-7
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:10652432-Animals,
pubmed-meshheading:10652432-Antigen Presentation,
pubmed-meshheading:10652432-Breast Neoplasms,
pubmed-meshheading:10652432-Cancer Vaccines,
pubmed-meshheading:10652432-Cytotoxicity, Immunologic,
pubmed-meshheading:10652432-Epitopes, T-Lymphocyte,
pubmed-meshheading:10652432-Female,
pubmed-meshheading:10652432-Fluorescence,
pubmed-meshheading:10652432-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:10652432-H-2 Antigens,
pubmed-meshheading:10652432-HLA-A2 Antigen,
pubmed-meshheading:10652432-Humans,
pubmed-meshheading:10652432-Mice,
pubmed-meshheading:10652432-Mice, Inbred C57BL,
pubmed-meshheading:10652432-Mice, Knockout,
pubmed-meshheading:10652432-Mice, Transgenic,
pubmed-meshheading:10652432-Mucin-1,
pubmed-meshheading:10652432-Peptide Fragments,
pubmed-meshheading:10652432-Peptides,
pubmed-meshheading:10652432-Protein Binding,
pubmed-meshheading:10652432-Recombinant Fusion Proteins,
pubmed-meshheading:10652432-T-Lymphocytes, Cytotoxic,
pubmed-meshheading:10652432-Tumor Cells, Cultured,
pubmed-meshheading:10652432-beta 2-Microglobulin
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pubmed:year |
2000
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pubmed:articleTitle |
Novel breast-tumor-associated MUC1-derived peptides: characterization in Db-/- x beta2 microglobulin (beta2m) null mice transgenic for a chimeric HLA-A2.1/Db-beta2 microglobulin single chain.
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pubmed:affiliation |
Department of Immunology, Weizmann Institute of Science, Rehovot, Israel.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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