Linked Life Data

10645271

Source:http://linkedlifedata.com/resource/pubmed/id/10645271

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2000-2-2
pubmed:abstractText
As spermatozoa pass through the epididymis they complete a maturation process that enables these cells to participate in the process of fertilization. Epididymal maturation involves a complex cascade of changes involving the remodelling of the sperm surface, the induction of chromatin condensation, the acquisition of movement, and development of the potential for capacitation. In this review we shall consider how changes in the redox status of mammalian spermatozoa may contribute to the completion of these maturation events. Spermatozoa from all regions of the epididymis exhibit a spontaneous capacity for superoxide anion production which can be enhanced by exposure to NADPH, particularly in the caput region. It is hypothesized that this spontaneous free radical generating activity is mediated by a membrane-bound NADPH oxidase, the function of which is to generate the peroxides that are needed to serve as hydrogen acceptors for phospholipid hydroperoxide glutathione peroxidase in the induction of sperm chromatin condensation. As spermatozoa enter the cauda epididymidis they also express a capacity for hydrogen peroxide (H2O2) generation when released into simple, defined culture media. The onset of this activity is thought to be associated with the induction of sperm capacitation through stimulation of the tyrosine phosphorylation events involved in the attainment of a capacitated state. It is concluded that sperm maturation is a dynamic, redox regulated process, any imbalance in which could lead to the production of spermatozoa that are compromised in terms of their potential for fertilization and the integrity of their DNA.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0449-3087
pubmed:author
pubmed:issnType
Print
pubmed:volume
53
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
109-18
pubmed:dateRevised
2005-11-16
pubmed:meshHeading
pubmed:year
1998
pubmed:articleTitle
Maturation of redox regulatory mechanisms in the epididymis.
pubmed:affiliation
MRC Reproductive Biology Unit, Edinburgh, UK.
pubmed:publicationType
Journal Article, Review