Linked Life Data

10631573

Source:http://linkedlifedata.com/resource/pubmed/id/10631573

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2000-2-15
pubmed:abstractText
Cell-mediated immune responses are essential for host control of intracellular infections. Toxoplasma gondii is a protozoan parasite that infects multiple vertebrate species and invades multiple cell types. Upon initial encounter with the immune system, the parasite rapidly induces production of the type-1 promoting cytokine IL-12 most likely from a subpopulation of dendritic cells. NK and T cells are then activated and triggered to synthesize IFN-gamma, the major mediator of host resistance during the acute and chronic phases of infection. During the acute phase, a concomitant IL-10 response dampens the systemic type-1 cytokine production and prevents lethal immunopathology. Cytokine (IFN-gamma und TNF-alpha) rather than cytotoxicity-based effector functions are more critical for protective immunity both during the acute and chronic phases of T. gondii infection. Both hemopoietic and non-hemopoietic cellular elements act as IFN-gamma and TNF-dependent effectors of host resistance. Type II iNOS-derived nitric oxide (NO) is required mainly for hemopoietic cell-derived effector cell activity in the central nervous system (CNS) during the chronic phase of infection. Nevertheless, in both the acute and chronic stages, IFN-gamma-dependent but iNOS-independent mechanism(s) play a major function in parasite control and their identification remains an important challenge for this field.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0171-2985
pubmed:author
pubmed:issnType
Print
pubmed:volume
201
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
240-7
pubmed:dateRevised
2011-10-27
pubmed:meshHeading
pubmed-meshheading:10631573-Acute Disease, pubmed-meshheading:10631573-Animals, pubmed-meshheading:10631573-Chronic Disease, pubmed-meshheading:10631573-Dendritic Cells, pubmed-meshheading:10631573-Humans, pubmed-meshheading:10631573-Immunity, Cellular, pubmed-meshheading:10631573-Interferon-gamma, pubmed-meshheading:10631573-Interleukin-10, pubmed-meshheading:10631573-Interleukin-12, pubmed-meshheading:10631573-Killer Cells, Natural, pubmed-meshheading:10631573-Lymphocyte Subsets, pubmed-meshheading:10631573-Nitric Oxide Synthase, pubmed-meshheading:10631573-Nitric Oxide Synthase Type II, pubmed-meshheading:10631573-T-Lymphocytes, pubmed-meshheading:10631573-Toxoplasma, pubmed-meshheading:10631573-Toxoplasmosis, pubmed-meshheading:10631573-Toxoplasmosis, Animal, pubmed-meshheading:10631573-Tumor Necrosis Factor-alpha
pubmed:year
1999
pubmed:articleTitle
Cell-mediated immunity to Toxoplasma gondii: initiation, regulation and effector function.
pubmed:affiliation
Immunobiology Section, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
pubmed:publicationType
Journal Article, Review