Source:http://linkedlifedata.com/resource/pubmed/id/10628801
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
2000-1-21
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| pubmed:abstractText |
As a potential prognostic factor, the proliferative activity of 131 squamous cell carcinomas (SCC) of the hypopharynx and 47 of their cervical lymph-node metastases was analyzed retrospectively by means of monoclonal antibody Ki-S11 immunostaining, which specifically detects the Ki-67 antigen on paraffin-embedded tissue. Median follow-up time was 37.6 months. Ki-S11 revealed distinctive patterns of proliferating cells related to the degree of differentiation. The proliferation fractions in the primaries and their lymph-node metastases did not differ significantly. Patients with high proliferating hypopharynx carcinomas (>45% labeled cells) had a significantly lower 5-year-survival rate (16%) than patients with low proliferating tumors, whose 5-year-survival rate was 30% (P=0.01). A statistically significant positive correlation was also observed between proliferative activity and lymph-node status (P=0.012). In conclusion, the proliferative activity as determined by means of Ki-S11 immunostaining is of prognostic value with respect to both survival and metastatic risk in SCC of the hypopharynx.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
|
| pubmed:issn |
0945-6317
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
435
|
| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
590-5
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| pubmed:dateRevised |
2004-11-17
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| pubmed:meshHeading |
pubmed-meshheading:10628801-Adult,
pubmed-meshheading:10628801-Aged,
pubmed-meshheading:10628801-Aged, 80 and over,
pubmed-meshheading:10628801-Antibodies, Monoclonal,
pubmed-meshheading:10628801-Carcinoma, Squamous Cell,
pubmed-meshheading:10628801-Cell Division,
pubmed-meshheading:10628801-Cell Nucleus,
pubmed-meshheading:10628801-Cohort Studies,
pubmed-meshheading:10628801-Female,
pubmed-meshheading:10628801-Humans,
pubmed-meshheading:10628801-Hypopharyngeal Neoplasms,
pubmed-meshheading:10628801-Immunoenzyme Techniques,
pubmed-meshheading:10628801-Ki-67 Antigen,
pubmed-meshheading:10628801-Lymph Nodes,
pubmed-meshheading:10628801-Lymphatic Metastasis,
pubmed-meshheading:10628801-Male,
pubmed-meshheading:10628801-Middle Aged,
pubmed-meshheading:10628801-Prognosis,
pubmed-meshheading:10628801-Survival Rate
|
| pubmed:year |
1999
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| pubmed:articleTitle |
Proliferation marker Ki-S11--a prognostic indicator for squamous cell carcinoma of the hypopharynx.
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| pubmed:affiliation |
Rush Cancer Institute, Rush-Presbyterian-St. Luke's Medical Center, Chicago, IL, USA.
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| pubmed:publicationType |
Journal Article
|