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rdf:type |
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lifeskim:mentions |
umls-concept:C0006141,
umls-concept:C0007427,
umls-concept:C0007600,
umls-concept:C0014597,
umls-concept:C0019704,
umls-concept:C0026140,
umls-concept:C0030657,
umls-concept:C0231204,
umls-concept:C0243077,
umls-concept:C0929301,
umls-concept:C1521761,
umls-concept:C1537068,
umls-concept:C2349975
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pubmed:issue |
2
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pubmed:dateCreated |
2000-2-8
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pubmed:abstractText |
Human immunodeficiency virus type 1 (HIV-1) growth in lymphocyte cultures was increased when the virus inoculum was incubated in breast milk. The enhancing effect of milk was abolished by anti-cathepsin D antibody or by pepstatin A, a cathepsin D inhibitor. The cathepsin D-producing CD4-negative MCF7 mammary cells supported the growth of some HIV-1 isolates. An MCF7 line chronically producing HIV-1 IIIb was obtained. Cathepsin D may induce conformational modification of viral gp120, allowing direct interaction with a coreceptor. We demonstrated the presence of CXCR4 mRNA in MCF7 cells.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/10623764-10199223,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10623764-10449278,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10623764-10459959,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10623764-10465172,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10623764-1421424,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10623764-2015114,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10623764-2736531,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10623764-2850525,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10623764-3546517,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10623764-3780754,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10623764-3881171,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10623764-6977634,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10623764-7576319,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10623764-7580836,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10623764-7594703,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10623764-7622881,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10623764-7649082,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10623764-7963705,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10623764-7983725,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10623764-8220241,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10623764-8627789,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10623764-8655737,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10623764-8663314,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10623764-9107243,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10623764-9302437,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10623764-9343234,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10623764-9518002,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10623764-9631135,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10623764-9641677,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10623764-9641684,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10623764-9888845
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cathepsin D,
http://linkedlifedata.com/resource/pubmed/chemical/Galactosylceramides,
http://linkedlifedata.com/resource/pubmed/chemical/HIV Envelope Protein gp120,
http://linkedlifedata.com/resource/pubmed/chemical/Pepstatins,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Viral,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, HIV,
http://linkedlifedata.com/resource/pubmed/chemical/Streptomyces pepsin inhibitor,
http://linkedlifedata.com/resource/pubmed/chemical/pepstatin
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0022-538X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
74
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1004-7
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:10623764-Animals,
pubmed-meshheading:10623764-Breast,
pubmed-meshheading:10623764-Cathepsin D,
pubmed-meshheading:10623764-Epithelial Cells,
pubmed-meshheading:10623764-Female,
pubmed-meshheading:10623764-Galactosylceramides,
pubmed-meshheading:10623764-Gene Expression,
pubmed-meshheading:10623764-HIV Envelope Protein gp120,
pubmed-meshheading:10623764-HIV-1,
pubmed-meshheading:10623764-Humans,
pubmed-meshheading:10623764-Milk,
pubmed-meshheading:10623764-Pepstatins,
pubmed-meshheading:10623764-RNA, Messenger,
pubmed-meshheading:10623764-RNA, Viral,
pubmed-meshheading:10623764-Receptors, HIV,
pubmed-meshheading:10623764-Tumor Cells, Cultured
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pubmed:year |
2000
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pubmed:articleTitle |
A human milk factor susceptible to cathepsin D inhibitors enhances human immunodeficiency virus type 1 infectivity and allows virus entry into a mammary epithelial cell line.
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pubmed:affiliation |
Department of Applied Genetics, Faculty of Science, Université Libre de Bruxelles, Brussels, Belgium. Kelmessa@sga.ulb.ac.be
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pubmed:publicationType |
Journal Article
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