Source:http://linkedlifedata.com/resource/pubmed/id/10617088
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
24
|
| pubmed:dateCreated |
2000-2-3
|
| pubmed:abstractText |
Tyr-c[D-Lys-Phe-Ala], YKFA, is a potent opioid peptide analog with subnanomolar IC50s toward mu and delta receptors. Transposing Phe and Tyr, a modification found to promote mu antagonist activity in opioid/somatostatin hybrids, gave surprisingly high mu agonist activities for several related analogs, considering the lack of a 1-position hydroxyl function.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
|
| pubmed:issn |
0960-894X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
20
|
| pubmed:volume |
9
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
3441-6
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:10617088-Amino Acid Sequence,
pubmed-meshheading:10617088-Chromatography, High Pressure Liquid,
pubmed-meshheading:10617088-Chromatography, Thin Layer,
pubmed-meshheading:10617088-Mass Spectrometry,
pubmed-meshheading:10617088-Oligopeptides,
pubmed-meshheading:10617088-Peptides, Cyclic,
pubmed-meshheading:10617088-Receptors, Opioid, mu
|
| pubmed:year |
1999
|
| pubmed:articleTitle |
Synthesis and biological activities of position one and three transposed analogs of the opioid peptide YKFA.
|
| pubmed:affiliation |
Department of Chemistry, University of Louisville, KY 40292 USA.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.
|