Linked Life Data

10616104

Source:http://linkedlifedata.com/resource/pubmed/id/10616104

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
2000-2-1
pubmed:abstractText
The aim of the present review is to discuss recent acquisitions on the neurophysiological effects of the DA denervation of the striatum, obtained in vitro from single neurone electrophysiological recordings. Nigrostriatal DA system degeneration does not significantly alter the intrinsic properties of striatal cells, but triggers adaptive responses in the striatum, involving glutamatergic neurotransmission. By pairing intracellular recordings from 6-OHDA-denervated striatal projection neurones and the synaptic stimulation of glutamatergic corticostriatal pathway, in vitro experiments contributed to elucidate the intimate alterations that follow striatal DA deafferentation. This experimental approach also allowed to better understand the possible cellular bases of both beneficial and side effects of the pharmacological compounds commonly employed in the treatment of PD.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1388-2457
pubmed:author
pubmed:issnType
Print
pubmed:volume
110
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2006-13
pubmed:dateRevised
2008-9-10
pubmed:meshHeading
pubmed:year
1999
pubmed:articleTitle
Neurophysiology of Parkinson's disease: from basic research to clinical correlates.
pubmed:affiliation
Clinica Neurologica, Dipartimento di Neuroscienze, Università di Tor Vergata, Rome, Italy.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't