| pubmed-article:10611343 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10611343 | lifeskim:mentions | umls-concept:C0887899 | lld:lifeskim |
| pubmed-article:10611343 | lifeskim:mentions | umls-concept:C0425152 | lld:lifeskim |
| pubmed-article:10611343 | lifeskim:mentions | umls-concept:C0205307 | lld:lifeskim |
| pubmed-article:10611343 | lifeskim:mentions | umls-concept:C1420062 | lld:lifeskim |
| pubmed-article:10611343 | lifeskim:mentions | umls-concept:C1439292 | lld:lifeskim |
| pubmed-article:10611343 | lifeskim:mentions | umls-concept:C1514485 | lld:lifeskim |
| pubmed-article:10611343 | pubmed:issue | 26 | lld:pubmed |
| pubmed-article:10611343 | pubmed:dateCreated | 2000-1-27 | lld:pubmed |
| pubmed-article:10611343 | pubmed:abstractText | P75/AIRM1 is a recently identified surface molecule that belongs to the sialoadhesin family and displays homology with the myeloid cell antigen CD33. In lymphoid cells, p75/AIRM1 is confined to natural killer cells and mediates inhibition of their cytolytic activity. In this study, we show that p75/AIRM1 is also expressed by cells of the myelomonocytic cell lineage, in which it appears at a later stage as compared with CD33. In vitro proliferation and differentiation of cord blood-derived CD34(+) cells (induced by stem cell factor and granulocyte-macrophage colony-stimulating factor) were consistently inhibited by the addition of anti-p75/AIRM1 mAb. Engagement of CD33 led to inhibition in some experiments. A sharp decrease of cell proliferation/survival was detected in all three p75/AIRM1+ chronic myeloid leukemias analyzed when cultured in the presence of either anti-p75/AIRM1 or anti-CD33 mAbs. Thus, the present study suggests that p75/AIRM1 and CD33 may play a regulatory role in normal myelopoiesis and may be viewed as suitable target molecules to counteract the proliferation/survival of chronic myeloid leukemias. | lld:pubmed |
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| pubmed-article:10611343 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:10611343 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:10611343 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10611343 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:10611343 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:10611343 | pubmed:author | pubmed-author:BacigalupoAA | lld:pubmed |
| pubmed-article:10611343 | pubmed:author | pubmed-author:FalckII | lld:pubmed |
| pubmed-article:10611343 | pubmed:author | pubmed-author:MingariM CMC | lld:pubmed |
| pubmed-article:10611343 | pubmed:author | pubmed-author:VitaliGG | lld:pubmed |
| pubmed-article:10611343 | pubmed:author | pubmed-author:MorettaLL | lld:pubmed |
| pubmed-article:10611343 | pubmed:author | pubmed-author:MorettaAA | lld:pubmed |
| pubmed-article:10611343 | pubmed:author | pubmed-author:PonteMM | lld:pubmed |
| pubmed-article:10611343 | pubmed:author | pubmed-author:VitaleMM | lld:pubmed |
| pubmed-article:10611343 | pubmed:author | pubmed-author:RomagnaniCC | lld:pubmed |
| pubmed-article:10611343 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10611343 | pubmed:day | 21 | lld:pubmed |
| pubmed-article:10611343 | pubmed:volume | 96 | lld:pubmed |
| pubmed-article:10611343 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10611343 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10611343 | pubmed:pagination | 15091-6 | lld:pubmed |
| pubmed-article:10611343 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:10611343 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10611343 | pubmed:articleTitle | Engagement of p75/AIRM1 or CD33 inhibits the proliferation of normal or leukemic myeloid cells. | lld:pubmed |
| pubmed-article:10611343 | pubmed:affiliation | Istituto Nazionale per la Ricerca sul Cancro, 16132 Genova, Italy. | lld:pubmed |
| pubmed-article:10611343 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10611343 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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