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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
26
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pubmed:dateCreated |
2000-1-27
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pubmed:abstractText |
P75/AIRM1 is a recently identified surface molecule that belongs to the sialoadhesin family and displays homology with the myeloid cell antigen CD33. In lymphoid cells, p75/AIRM1 is confined to natural killer cells and mediates inhibition of their cytolytic activity. In this study, we show that p75/AIRM1 is also expressed by cells of the myelomonocytic cell lineage, in which it appears at a later stage as compared with CD33. In vitro proliferation and differentiation of cord blood-derived CD34(+) cells (induced by stem cell factor and granulocyte-macrophage colony-stimulating factor) were consistently inhibited by the addition of anti-p75/AIRM1 mAb. Engagement of CD33 led to inhibition in some experiments. A sharp decrease of cell proliferation/survival was detected in all three p75/AIRM1+ chronic myeloid leukemias analyzed when cultured in the presence of either anti-p75/AIRM1 or anti-CD33 mAbs. Thus, the present study suggests that p75/AIRM1 and CD33 may play a regulatory role in normal myelopoiesis and may be viewed as suitable target molecules to counteract the proliferation/survival of chronic myeloid leukemias.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/10611343-10358776,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10611343-10499918,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10611343-1374051,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10611343-1711562,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10611343-2147946,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10611343-2469766,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10611343-3390608,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10611343-7718872,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10611343-8306247,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10611343-8627166,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10611343-8717527,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10611343-9143697,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10611343-9465907,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10611343-9626458,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10611343-9815888
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD34,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation...,
http://linkedlifedata.com/resource/pubmed/chemical/CD33 antigen,
http://linkedlifedata.com/resource/pubmed/chemical/Granulocyte-Macrophage...,
http://linkedlifedata.com/resource/pubmed/chemical/Hepatocyte Growth Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Immunologic
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
21
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pubmed:volume |
96
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
15091-6
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:10611343-Antibodies, Monoclonal,
pubmed-meshheading:10611343-Antigens, CD,
pubmed-meshheading:10611343-Antigens, CD34,
pubmed-meshheading:10611343-Antigens, Differentiation, Myelomonocytic,
pubmed-meshheading:10611343-Cell Division,
pubmed-meshheading:10611343-Cell Lineage,
pubmed-meshheading:10611343-Culture Techniques,
pubmed-meshheading:10611343-Granulocyte-Macrophage Colony-Stimulating Factor,
pubmed-meshheading:10611343-Hematopoietic Stem Cells,
pubmed-meshheading:10611343-Hepatocyte Growth Factor,
pubmed-meshheading:10611343-Humans,
pubmed-meshheading:10611343-Immunologic Capping,
pubmed-meshheading:10611343-Immunomagnetic Separation,
pubmed-meshheading:10611343-Leukemia, Myelogenous, Chronic, BCR-ABL Positive,
pubmed-meshheading:10611343-Monocytes,
pubmed-meshheading:10611343-Receptors, Immunologic
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pubmed:year |
1999
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pubmed:articleTitle |
Engagement of p75/AIRM1 or CD33 inhibits the proliferation of normal or leukemic myeloid cells.
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pubmed:affiliation |
Istituto Nazionale per la Ricerca sul Cancro, 16132 Genova, Italy.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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