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pubmed-article:10607611pubmed:abstractTextA restriction enzyme gene is often linked to a modification methylase gene the role of which is to protect a recognition site on DNA from breakage by the former. Loss of some restriction-modification gene complexes leads to cell death through restriction breakage in the genome. Their behavior as genomic parasites/symbionts may explain the distribution of restriction sites and clarify certain aspects of bacterial recombination repair and mutagenesis. A comparison of bacterial genomes supports the hypothesis that restriction-modification gene complexes are mobile elements involved in various genome rearrangements and evolution.lld:pubmed
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pubmed-article:10607611pubmed:articleTitleShaping the genome--restriction-modification systems as mobile genetic elements.lld:pubmed
pubmed-article:10607611pubmed:affiliationInstitute of Medical Science, University of Tokyo, Shirokanedai, 108-8639, Japan. ikobaya@ims.u-tokyo.ac.jplld:pubmed
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