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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2000-1-19
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pubmed:abstractText |
Mouse splenic dendritic cells (DCs) produce IFN-gamma in response to IL-12. In the present study, we analyzed effects of Th1 and Th2 cytokines on IFN-gamma production by DCs. IL-18 produced by DCs and macrophages acts in an autocrine manner and augments IL-12-induced IFN-gamma production by DCs as also observed in T and NK cells. Surprisingly, IL-4, a Th2 cytokine, also acts synergistically with IL-12 on IFN-gamma production by DCs. In addition, IL-4 markedly enhances IFN-gamma production when DCs are stimulated through CD40 or MHC class II. These results indicate that both Th1 and Th2 cytokines act on DCs during T cell-DC interaction upon Ag presentation. p38 mitogen-activated protein kinase is constitutively activated in mature DCs and is required for IFN-gamma production by DCs. IL-18 but not IL-4 or IL-12 further activates the p38 mitogen-activated protein kinase activity, suggesting that IL-4 and IL-18 enhance IFN-gamma production through distinct intracellular signal transduction pathways in DCs.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adjuvants, Immunologic,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD40,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD8,
http://linkedlifedata.com/resource/pubmed/chemical/Histocompatibility Antigens Class II,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-12,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-18,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-4,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukins,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/p38 Mitogen-Activated Protein...
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0022-1767
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
164
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
64-71
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:10604994-Adjuvants, Immunologic,
pubmed-meshheading:10604994-Animals,
pubmed-meshheading:10604994-Antigens, CD40,
pubmed-meshheading:10604994-Antigens, CD8,
pubmed-meshheading:10604994-Dendritic Cells,
pubmed-meshheading:10604994-Drug Synergism,
pubmed-meshheading:10604994-Enzyme Activation,
pubmed-meshheading:10604994-Histocompatibility Antigens Class II,
pubmed-meshheading:10604994-Interferon-gamma,
pubmed-meshheading:10604994-Interleukin-12,
pubmed-meshheading:10604994-Interleukin-18,
pubmed-meshheading:10604994-Interleukin-4,
pubmed-meshheading:10604994-Interleukins,
pubmed-meshheading:10604994-Lymphocyte Subsets,
pubmed-meshheading:10604994-Macrophages,
pubmed-meshheading:10604994-Mice,
pubmed-meshheading:10604994-Mice, Inbred C57BL,
pubmed-meshheading:10604994-Mitogen-Activated Protein Kinases,
pubmed-meshheading:10604994-Monocytes,
pubmed-meshheading:10604994-p38 Mitogen-Activated Protein Kinases
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pubmed:year |
2000
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pubmed:articleTitle |
Synergistic effects of IL-4 and IL-18 on IL-12-dependent IFN-gamma production by dendritic cells.
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pubmed:affiliation |
Department of Microbiology and Immunology, Keio University School of Medicine, Tokyo, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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