Linked Life Data

10602519

Source:http://linkedlifedata.com/resource/pubmed/id/10602519

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
52
pubmed:dateCreated
2000-1-13
pubmed:databankReference
pubmed:abstractText
Although most extraskeletal myxoid chondrosarcomas (EMC) are cytogenetically characterized by the translocation t(9;22)(q22;q12), another subset has recently been identified carrying a t(9;17)(q22;q11). Whereas the t(9;22) is known to result in fusion of the CHN (TEC) gene from 9q22 with the EWS gene from 22q12, creating a chimeric EWS/CHN, the genes involved in the t(9;17) of EMC are unknown. We examined two EMC with t(9;17)(q22;q11) and found that the CHN gene was recombined with the RBP56 gene from 17q11 to generate a chimeric RBP56/CHN. RBP56 has not previously been shown to be involved in tumorigenesis but it encodes a putative RNA-binding protein similar to the EWS and FUS (TLS) proteins known to play a pathogenetic role in several sarcomas. The presence of the RBP56/CHN chimeric gene in EMC with t(9;17)(q22;q11) shows that the N-terminal parts of EWS and RBP56 have similar oncogenic potential making them pathogenetically equivalent in oncoproteins arising from fusions with certain transcription factors.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0950-9232
pubmed:author
pubmed:issnType
Print
pubmed:day
9
pubmed:volume
18
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
7594-8
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:10602519-Amino Acid Sequence, pubmed-meshheading:10602519-Artificial Gene Fusion, pubmed-meshheading:10602519-Base Sequence, pubmed-meshheading:10602519-Chondrosarcoma, pubmed-meshheading:10602519-Chromosomes, Human, Pair 17, pubmed-meshheading:10602519-Chromosomes, Human, Pair 9, pubmed-meshheading:10602519-DNA-Binding Proteins, pubmed-meshheading:10602519-Humans, pubmed-meshheading:10602519-Molecular Sequence Data, pubmed-meshheading:10602519-Nerve Tissue Proteins, pubmed-meshheading:10602519-Nuclear Proteins, pubmed-meshheading:10602519-Receptors, Steroid, pubmed-meshheading:10602519-Receptors, Thyroid Hormone, pubmed-meshheading:10602519-TATA-Binding Protein Associated Factors, pubmed-meshheading:10602519-Transcription Factors, pubmed-meshheading:10602519-Translocation, Genetic
pubmed:year
1999
pubmed:articleTitle
Fusion of the RBP56 and CHN genes in extraskeletal myxoid chondrosarcomas with translocation t(9;17)(q22;q11).
pubmed:affiliation
Department of Clinical Genetics, Lund University Hospital, S-221 85 Lund, Sweden.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't