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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6 Pt 1
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pubmed:dateCreated |
2000-1-20
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pubmed:abstractText |
The migration of intestinal cells is important in the development and maintenance of normal epithelium, in a process that may be regulated by growth factors and cytokines. Although a number of growth factor receptors are expressed by intestinal cells, little progress has been made toward assignment of functional roles for these ligand-receptor systems. This study compares several growth factors and cytokines for their chemoattraction of the mouse small intestinal epithelial cell line. Epidermal and hepatocyte growth factors stimulated a rapid 30-fold chemotaxis of cells with delayed threefold migration toward transforming growth factor-beta1. Despite stimulating proliferation, keratinocyte, fibroblast, or insulin-like growth factors did not stimulate directed migration. Chemotaxis required tyrosine kinase and phosphatidylinositol phospholipase C activities but not protein kinase C or mitogen-activated protein kinase activity. These findings suggest that the repertoire of growth factors capable of regulating directed intestinal epithelial cell migration is limited and that a divergence exists in the signal transduction pathways for directed vs. nondirected migration.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Epidermal Growth Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Fgf7 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Fibroblast Growth Factor 1,
http://linkedlifedata.com/resource/pubmed/chemical/Fibroblast Growth Factor 10,
http://linkedlifedata.com/resource/pubmed/chemical/Fibroblast Growth Factor 2,
http://linkedlifedata.com/resource/pubmed/chemical/Fibroblast Growth Factor 7,
http://linkedlifedata.com/resource/pubmed/chemical/Fibroblast Growth Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Flavonoids,
http://linkedlifedata.com/resource/pubmed/chemical/Genistein,
http://linkedlifedata.com/resource/pubmed/chemical/Growth Substances,
http://linkedlifedata.com/resource/pubmed/chemical/Hepatocyte Growth Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin-Like Growth Factor I,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinase 1,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinase 3,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Naphthalenes,
http://linkedlifedata.com/resource/pubmed/chemical/PD 98059,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Epidermal Growth Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Transforming Growth Factor beta,
http://linkedlifedata.com/resource/pubmed/chemical/Type C Phospholipases,
http://linkedlifedata.com/resource/pubmed/chemical/Tyrphostins,
http://linkedlifedata.com/resource/pubmed/chemical/calphostin C,
http://linkedlifedata.com/resource/pubmed/chemical/tyrphostin AG 1478
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0002-9513
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
277
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
C1149-59
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:10600766-Animals,
pubmed-meshheading:10600766-Cell Division,
pubmed-meshheading:10600766-Cell Line, Transformed,
pubmed-meshheading:10600766-Chemotaxis,
pubmed-meshheading:10600766-Enzyme Inhibitors,
pubmed-meshheading:10600766-Epidermal Growth Factor,
pubmed-meshheading:10600766-Epithelial Cells,
pubmed-meshheading:10600766-Extracellular Matrix,
pubmed-meshheading:10600766-Fibroblast Growth Factor 1,
pubmed-meshheading:10600766-Fibroblast Growth Factor 10,
pubmed-meshheading:10600766-Fibroblast Growth Factor 2,
pubmed-meshheading:10600766-Fibroblast Growth Factor 7,
pubmed-meshheading:10600766-Fibroblast Growth Factors,
pubmed-meshheading:10600766-Flavonoids,
pubmed-meshheading:10600766-Genistein,
pubmed-meshheading:10600766-Growth Substances,
pubmed-meshheading:10600766-Hepatocyte Growth Factor,
pubmed-meshheading:10600766-Insulin-Like Growth Factor I,
pubmed-meshheading:10600766-Intestines,
pubmed-meshheading:10600766-Mice,
pubmed-meshheading:10600766-Mitogen-Activated Protein Kinase 1,
pubmed-meshheading:10600766-Mitogen-Activated Protein Kinase 3,
pubmed-meshheading:10600766-Mitogen-Activated Protein Kinases,
pubmed-meshheading:10600766-Naphthalenes,
pubmed-meshheading:10600766-Receptor, Epidermal Growth Factor,
pubmed-meshheading:10600766-Transforming Growth Factor beta,
pubmed-meshheading:10600766-Type C Phospholipases,
pubmed-meshheading:10600766-Tyrphostins
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pubmed:year |
1999
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pubmed:articleTitle |
Epidermal and hepatocyte growth factors stimulate chemotaxis in an intestinal epithelial cell line.
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pubmed:affiliation |
Division of Pediatric Gastroenterology and Nutrition, Department of Pediatrics, Vanderbilt University, Nashville, Tennessee 37232-2576, USA. d-brent.polk@mcmail.vanderbilt.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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